10-day course of penicillin V 250 mg twice daily in children
500 mg twice daily or 250 mg 4 times daily in adults
A single intramuscular injection of 1.2 million units of penicillin G benzathine can be administered in patients who weigh more than 27 kg; 600,000 units is used in patients who weigh less than 27 kg.
Amoxicillin is equally effective and may be better tolerated in children.
In patients who are allergic to penicillin, erythromycin or the newer macrolides (eg, azithromycin, clarithromycin) appear to be effective. Oral cephalosporins are also highly effective in the treatment of streptococcal pharyngitis.