Immune System

Immune System
Innate
Adaptive
Cellular Defense
Active Immunity
Passive Immunity
Non Specific
Specific
Primary Defense mechanism
respond immediately
Not Antigen specific
No Memory
Second line of defense
Require time to respond
Antigen specific
Have Memory
Physical Barriers
Chemical Mediators
Skin, Mouth,stomach Intestines, Lungs
inflammation, phagocytosis
Neutrophils
Lysozyme, Complements, Lactoferrin, interferons
Complement
Alternative
No Ab needed
Classical
AB needed (IgG, IgM)
AB + Ag Activates Complement
LPS, Peptidoglycan can activate complement
Macrophages
Animal produces its own AB
Persist years
Acquisition of immune factors produced in another animal
Persist weeks to months
Cell Mediated Immunity
Antibody Mediated immunity (HUMORAL)
effector T-Cells
TH cells (CD4+)
TC cells (CD8+)
B-Lymphocytes
Recognize antigens on surface of cells
Kill tumor, virus-infected cells)
Memory T-cells
Mediated by antibodies
B-memory Cells
can be transferred by lymphocytes
Can be transferred by antibodies or serum
NK cells
Proffesional phagocytes
phagocytic cell
constitute 70% of circulating WBC
Complement
1. Inflamatory Factors C3a C5a
2. Attraction of Phagocytes
3. Enhancement of phagocytic engulfment
4. Lysis of bacteria cell
Cascade Reaction
AB
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