Binding to GPCR

Disssociaiton of Gs

Activation of adenylyl cyclase

Secondary messenger - cAMP

Phosphorylation of PFK2/FBPase2; reduced F26BP

Phosphorylation of pyruvate kinase

Phosphorylation of Glycogen synthase

Phosphorylation of Phosphorylae b kinase b to a, Phosphorylation of glycogen phosphorylase

Phosphorylation of Inhibitor protein-1

Covalent modification of phosphorylation at Post translational level

Binding to CRE

Transcriptional activation of PEPCK

Transcriptional gene regulation

Insulin

Glycogenesis

Gluconeogenesis, Glycogenolysis

Glycolysis, Glycogenesis

Gluconeogenesis

Transcriptional gene regulation