Integrated regulation of carbohydrate metabolism

Jaci

A comprehensive mind map about the integrated regulation of carbohydrate metabolism.

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Outline

Integrated regulation

Low blood glucose

Glucagon

Binding to GPCR

Disssociaiton of Gs

Activation of adenylyl cyclase

Secondary messenger - cAMP

cAMP

CDPK/PKA activation

Phosphorylation of PFK2/FBPase2; reduced F26BP

Glycolysis

Gluconeogenesis

Phosphorylation of pyruvate kinase

Glycolysis

Phosphorylation of Glycogen synthase

Glycogenesis

Phosphorylation of Phosphorylae b kinase b to a, Phosphorylation of glycogen phosphorylase

Glycogenolysis

Phosphorylation of Inhibitor protein-1

Protein phosphatase

Ensures Inhibition of Glycolysis and Glycogenesis

Covalent modification of phosphorylation at Post translational level

Binding to CREBP

Binding to CRE

Transcriptional activation of PEPCK

Gluconeogenesis

Transcriptional gene regulation

PIP3

PKB/AKT activation

Activation of PDK-1

Activaiton of PKB

High blood glucose

Insulin

Binding to IR

Phosphorylation of IRS-1

Activation of PI3K

Secondary messenger PIP3

PKB/AKT

Phosphorylation of GSK3, inhibiting GSK3

Glycogenesis

Activation of Phosphodiesterase, reduced cAMP

Gluconeogenesis, Glycogenolysis

Glycolysis, Glycogenesis

Covalent modification

Phosphorylation of FOXO1, degradation of FOXO-1, Transcriptional repression of PEPCK, Glucose 6-phosphatase

Gluconeogenesis

Transcriptional gene regulation