Integrated regulation of carbohydrate metabolism
A comprehensive mind map about the integrated regulation of carbohydrate metabolism.
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Glucagon
Binding to GPCR
Disssociaiton of Gs
Activation of adenylyl cyclase
Secondary messenger - cAMP

CDPK/PKA activation
Phosphorylation of PFK2/FBPase2; reduced F26BP


Phosphorylation of pyruvate kinase

Phosphorylation of Glycogen synthase

Phosphorylation of Phosphorylae b kinase b to a, Phosphorylation of glycogen phosphorylase

Phosphorylation of Inhibitor protein-1



Binding to CREBP
Binding to CRE
Transcriptional activation of PEPCK



PKB/AKT activation
Activation of PDK-1
Activaiton of PKB

Insulin
Binding to IR
Phosphorylation of IRS-1
Activation of PI3K
Secondary messenger PIP3

Phosphorylation of GSK3, inhibiting GSK3

Activation of Phosphodiesterase, reduced cAMP



Phosphorylation of FOXO1, degradation of FOXO-1, Transcriptional repression of PEPCK, Glucose 6-phosphatase

