Mind Map Gallery Integrated regulation of carbohydrate metabolism
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A comprehensive mind map about the integrated regulation of carbohydrate metabolism.
Integrated regulation
Low blood glucose
Glucagon
Binding to GPCR
Disssociaiton of Gs
Activation of adenylyl cyclase
Secondary messenger - cAMP
cAMP
CDPK/PKA activation
Phosphorylation of PFK2/FBPase2; reduced F26BP
Glycolysis
Gluconeogenesis
Phosphorylation of pyruvate kinase
Phosphorylation of Glycogen synthase
Glycogenesis
Phosphorylation of Phosphorylae b kinase b to a, Phosphorylation of glycogen phosphorylase
Glycogenolysis
Phosphorylation of Inhibitor protein-1
Protein phosphatase
Ensures Inhibition of Glycolysis and Glycogenesis
Covalent modification of phosphorylation at Post translational level
Binding to CREBP
Binding to CRE
Transcriptional activation of PEPCK
Transcriptional gene regulation
PIP3
PKB/AKT activation
Activation of PDK-1
Activaiton of PKB
High blood glucose
Insulin
Binding to IR
Phosphorylation of IRS-1
Activation of PI3K
Secondary messenger PIP3
PKB/AKT
Phosphorylation of GSK3, inhibiting GSK3
Activation of Phosphodiesterase, reduced cAMP
Gluconeogenesis, Glycogenolysis
Glycolysis, Glycogenesis
Covalent modification
Phosphorylation of FOXO1, degradation of FOXO-1, Transcriptional repression of PEPCK, Glucose 6-phosphatase