Integrated regulation of carbohydrate metabolism

Glycolysis
Gluconeogenesis
Glycolysis
Glycogenesis
Glycogenolysis
Protein phosphatase
Ensures Inhibition of Glycolysis and Glycogenesis
Gluconeogenesis
Glycogenesis
Gluconeogenesis, Glycogenolysis
Glycolysis, Glycogenesis
Gluconeogenesis
Integrated regulation
Low blood glucose
cAMP
PIP3
High blood glucose
CDPK/PKA activation
Binding to CREBP
Phosphorylation of PFK2/FBPase2; reduced F26BP
Phosphorylation of pyruvate kinase
Phosphorylation of Glycogen synthase
Phosphorylation of Phosphorylae b kinase b to a, Phosphorylation of glycogen phosphorylase
Binding to CRE
Transcriptional activation of PEPCK
Insulin
Binding to IR
Activation of PI3K
PKB/AKT activation
Activation of PDK-1
Activaiton of PKB
Glucagon
Binding to GPCR
Disssociaiton of Gs
Activation of adenylyl cyclase
Secondary messenger - cAMP
Phosphorylation of Inhibitor protein-1
Covalent modification of phosphorylation at Post translational level
Transcriptional gene regulation
Phosphorylation of IRS-1
Secondary messenger PIP3
PKB/AKT
Phosphorylation of GSK3, inhibiting GSK3
Activation of Phosphodiesterase, reduced cAMP
Phosphorylation of FOXO1, degradation of FOXO-1, Transcriptional repression of PEPCK, Glucose 6-phosphatase
Transcriptional gene regulation
Covalent modification
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