This is a mind map about Basic Concepts of Pharmacodynamics. The study of a drug's biochemical and physiological consequences is known as pharmacodynamics. The impacts may appear in humans, animals, microbes, or assemblages of creatures. In EdrawMind community, you can get more templates of mind maps or other topics in study, work and life.
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pharmacodynamics
Drug Safet
ED50
dose produce 50% of Emax in one animal
TD50
the dose needed to cause harmful effect in 50%of tested population
LD50
the dose needed to cause death in 50% in tested group (animals)
Therapeutic Index
TD50/ED50
safety measure
higher TI=safer
Drug Antagonism
types
pharmacological
dynamics
competitive
kinetics
absorption (decrease)
antacids-->Fe&aspirin
distribution
metabolism(increase)
rifampicin-->contraceptive pills
excretion(increase)
NaHCO3-->aspirin
physiological
2 drugs-opposite effects-different receptors
adrenaline(^BP&B.D.)-->histamine(decrease BP &B.C.)
physical
2 drugs-opposite charges
protamine(+ve)+heparin(-ve)=neutralization
chemical
acidic+basic-->precepitation
gentamycin(basic)+carbenicillin(acidic)in the same syringe=chemical complex
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pharmacodynamics
Drug Safet
