Synthesis

PG is a type of highly active inflammatory mediator in inflammatory reactions, which can dilate blood vessels, increase microvascular permeability, induce heat, attract neutrophils, etc.

Mechanism: Inhibiting the biosynthesis of COX in the body - reducing PG production

Features: Anti-inflammatory but not antibacterial, it targets the symptoms but not the cause; it works quickly, relieves pain and reduces inflammation

Inhibition of PG synthesis - reduced sensitivity of local pain receptors to bradykinin and other pain-causing substances

Features: Especially effective for dull inflammatory pain; ineffective for acute sharp pain and visceral colic; no euphoria, no respiratory depression; no dependence or tolerance for long-term use (relative to sedative-hypnotic drugs)

Mechanism of action: Inhibits the synthesis of PG in the hypothalamus - exerts antipyretic effect

Process in the body: Rapidly absorbed after oral administration, it is a weak organic acid (detoxifies and alkalizes urine); liver metabolism; kidney excretion

Pharmacological effects and clinical applications

Adverse reactions

medicine interactions

Pharmacological effects: Antipyretic and analgesic are similar to aspirin, but the anti-inflammatory effect is extremely weak

No obvious gastrointestinal irritation

Can be used in children