心智圖資源庫 病理學—淋巴系統疾病
病理學—淋巴系統疾病思維導圖,病理學考試重點,包含何杰金氏淋巴瘤 (HD)、非何杰金氏淋巴瘤等。
編輯於2024-01-12 22:59:24This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
淋巴系統疾病
標記(腫瘤的模擬性—形態、免疫表型的模擬性)
T細胞:CD2、3、4、7、8
B細胞:CD10、19、20、79a、Sig、PAX5
NK細胞:CD16,56
T/B淋巴母細胞:CD34,TdT
髓樣細胞腫瘤:CD13、33、117、MPO
霍奇金淋巴瘤(HD)
特點
青年常見,約佔全部淋巴瘤的10%-20%
原發於淋巴結,從一組淋巴結由近及遠擴散
首發症狀—無痛性,進行性腫大
R-S細胞(診斷依據),典型R-S細胞(鏡影細胞)
起源於B細胞,但免疫標記為CD15,CD30
預後良好
分類
結節性淋巴球為主型
病灶結節樣
背景
小淋巴球多
特徵細胞
爆米花細胞
免疫
CD20
預後最好
經典型
結節硬化型
常見女青年
大量膠原纖維增生分割淋巴結呈大小不等的境界清楚的結節
特徵細胞—陷窩細胞,典型R-S細胞少
免疫—CD15,CD30
混合細胞型
50歲以上常見,男性
特徵細胞—典型R-S,散在霍奇金細胞(單核)
背景複雜—淋巴球,漿細胞,嗜酸性球
免疫—CD15,CD30
富於淋巴球型
較少見,預後好
典型R-S細胞,散在霍奇金細胞
背景—小淋巴球,組織細胞多
免疫—CD15,CD30
淋巴球減少型
最少見,預後差
R-S細胞/多形R-S細胞相對較多
免疫—CD15,CD30
非何杰金氏淋巴瘤
特點
約佔所有淋巴瘤80%-90%
2/3原發淋巴結,1/3原發淋巴結外器官或組織
易向其他淋巴結和全身器官組織擴散
類型
前B細胞和T細胞腫瘤(急性淋巴母細胞白血病)
高度侵襲性
TdT陽性
發病年齡小
週邊B細胞腫瘤
慢性淋巴球白血病/小淋巴球淋巴瘤
常見中老年,男性
惰性腫瘤
病變特點
幼稚淋巴球浸潤聚集增生→假濾泡
缺乏y球蛋白,容易細菌感染
濾泡性淋巴瘤
常見中老年
惰性B細胞腫瘤
bcl-2陽性(區別反應性增生的濾泡和腫瘤性濾泡的標記)
約有40%可能性轉變為瀰漫大B細胞淋巴瘤—p53突變
瀰漫性大B淋巴瘤
老年人
侵襲性高
bcl-6基因突變
Burkitt淋巴瘤
高度惡性,與EBV感染有關
非洲多見,兒童青少年
發生部位結外器官組織受累
鏡下—滿天星
免疫標記—bcl6
但大劑量化療,大多數病人可以痊癒
黏膜相關淋巴組織淋巴瘤
與HP感染有關
多發性骨髓瘤(漿細胞相關腫瘤)
週邊T和NK細胞腫瘤
週邊T細胞淋巴瘤
高度侵襲性
NK/T細胞淋巴瘤
我國最常見的T細胞淋巴瘤
高度惡性
發生於結外,尤其鼻部
鏡下
凝固性壞死,發炎細胞浸潤
嗜血管性
細胞多形性
蕈樣黴菌病