ACHReceotors
Muscarinic
Agonists
Pilocarp ine(used to treat glaucoma via M3)
Met hacho line(diagnose asthma, causes bronchoconstr iction)
Bethanecol(b ladder contraction, trats urinary retention via M3)
Antagonists
Atropine (treats muschroom poisoning , prevents bronchoconstr iction)
Hyoscine (anti- emetic . Motons ickness)
piren zepine (M1 , inhibits gastric acid sec retion - trests uicers)
Benztro pine ( anti - parkinson ian dyskinesia)
Ipratropium (bronchodillation - treats as thma)
Nicotonic
Agonists
Carbach ol (treat glaucome)
Su xametho nium(depolar ising blocker - muscle relax ant .Is a partial agonist- prevents furtherdepoler is ation so has antagon is tic effects)
Antagonists
Botulinum(prevents presynaptic ACh ree ase)
Tubocurar in e analo gues: mivacur iu m, atracurium, vecuro nium , pancuro nium (blocks ACh binding- muscle relaxanf)
ACHEInhibitors
Short-acting 4 alcohol
Edrophonium- diagnoses MG- revers be binding to anionic site
Medium- acting carbamyl ester
Neosting mine - MGPhysostigmine- MG, alzheimers, delayed gastric e mpty ing
Irreversible block
Echothiopate & dyflos eye drops for glaucoma (pe ntavalent p hosp horus compounds)(reversed by pralidoxime+M antgonist (at rop ine) in first 1-2 hours)
Non-specific
Agonists
adrena line(increases HR, constrcts blood vessels, diates air pas sages.actions vary by tissue type and expression of adrenergic rece ptors.
B1=B2
Agonists
Iso prenaline(treats bradyc ardia , astham. contra-indicated for my ocardial ischemia)
Antagonists
Propranolol(treats tachycardia)
B2
Agonists
Terbutaline & Salbutamol(bronchodlators. Saibutamol also used to today labour)
B1
Agonists
Dobutamine(treats heart failure and c ardio shock)
Antagonists
Metopro lol & Ate nolol(treat cardiseas es)
a2
Agonists
Clonid ine(treats high BP)
a1
Agonists
Phenylephrine(deco nges tant, inc reases BP)
Antagonists
Prazosin (treats high bbod pressure , anxiety, PTSD
Sympathomimetcs = adrenergc agonistssympathomimetcs=adrenergc a nta gonists
a receptors are in blood v essels, cause contraction, the refore increas e BP
B1 rec eptors are in heart: increase HR, COB2 rec eptors cause smooth muscle re laxation (bladder, bronchi, uterus)
Sympathomimetcs = adrenergc agonistssympathomimetcs=adrenergc a nta gonists
a receptors are in blood v essels, cause contraction, the refore increas e BP
B1 rec eptors are in heart: increase HR, COB2 rec eptors cause smooth muscle re laxation (bladder, bronchi, uterus)
Muscarinic Excess->DUMBELSDefecationUrinationMosis (Puplis contract)BronchoconstrictionEmesisLacrimationSalvation
Muscarinic AChR found in receptorsof Parasympathic Innervatiion(exception - MACHR in Sweatglands are sympathetic
M1 - neural & GI motility - excitationM2 - Cardiac Inhbtion - InhibitionM3 - glandular secretions andvasodlation via No - excitation
Nicotonic AChR foundin Skeletal muscle andall postgang fonicneurone in ANS
AChE Inhibitors are indirectchollnergic agonists - theyincrease the effects of AChat the re Ceptor. Mainly Meffects seen at low does.Toxic gases usesd in Syriaand as linse cticides