MindMap Gallery Drug Distribution
Drug distribution refers to the process by which illegal substances are manufactured, transported, and sold, often leading to addiction, crime, and societal harm. Drug distribution is a complex and multifaceted issue that impacts individuals, communities, and societies at large. This mind map aims to explore the various aspects of drug distribution. y engaging with this mind map, we can develop a deeper awareness of the complexities surrounding drug distribution and contribute to the development of effective solutions to combat this issue.
Edited at 2023-02-16 01:33:24Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Drug Distribution
According to blood supply body organs classification
High perfused organs.
High perfused organs are organs with high blood flow
Heart, liver, Kidney and Brain and other well perfused organs
High perfused organs receive most of the drug during the first few minutes after absorption.
Low perfused organs
Low perfused organs are organs with have lower blood flow
e.g. Muscles, skin and fat
Delivery of the drug to these larger fraction of body mass is slower and is also limited by blood flow to these organs.
Drug Distribution
what is drung distribution
After a drug enters the general circulation, it is carried with the blood stream and is distributed to various body tissues.
phases
First Phase
liver, kidney, brain, and other well-perfused organs receive most of the drug
The second Phase
involves a far larger fraction of body mass (e.g., muscle)
accounts for most of the extravascular distribution
require minutes to several hours before the concentration of drug in tissue is in equilibrium with that in blood.
Factors affecting drug distribution
affect the rate of delivery and amount of drug distributed into tissues
Physicochemical properties of the drug,
Capacity of the regions to interact with the drug.
Cardiac output,
Regional blood flow.
Capillary permeability,
Tissue volume.
Diffusion to CNS, the BBB, and CSF
brain capillary endothelial cells have continuous tight junctions
drug penetration into the brain depends on transcellular transport
pericapillary glial cells constitute the BBB.
the more lipophilic a drug, the more likely it is to cross the BBB.
meningeal and encephalic inflammation increase local permeability.
Bone as drug Reservoir
Tetracycline antibiotics and heavy metals may accumulate in bone by adsorption
Bone can become a reservoir for the slow release of toxic agents such as lead or radium
effect persist long after exposure
reduced blood flow due to distruction of local orgins
greater the exposure to the toxic agent, the slower is its rate of elimination
Fat as a Reservoir
Many lipid-soluble drugs are stored by physical solution in the neutral fat.
fat may serve as a reservoir for lipid-soluble drugs.
Example of drugs stored in fats
Some anti anxiety medications, like clorazepate, and
Certain antibiotics such as rifampicin.