MindMap Gallery Blood - components and functions
Introduction to blood components, functions of each component, analysis of indicators, detailed introduction, and comprehensive description. I hope it will be helpful to interested friends!
Edited at 2024-02-11 23:11:06Avatar 3 centers on the Sully family, showcasing the internal rift caused by the sacrifice of their eldest son, and their alliance with other tribes on Pandora against the external conflict of the Ashbringers, who adhere to the philosophy of fire and are allied with humans. It explores the grand themes of family, faith, and survival.
This article discusses the Easter eggs and homages in Zootopia 2 that you may have discovered. The main content includes: character and archetype Easter eggs, cinematic universe crossover Easter eggs, animal ecology and behavior references, symbol and metaphor Easter eggs, social satire and brand allusions, and emotional storylines and sequel foreshadowing.
[Zootopia Character Relationship Chart] The idealistic rabbit police officer Judy and the cynical fox conman Nick form a charmingly contrasting duo, rising from street hustlers to become Zootopia police officers!
Avatar 3 centers on the Sully family, showcasing the internal rift caused by the sacrifice of their eldest son, and their alliance with other tribes on Pandora against the external conflict of the Ashbringers, who adhere to the philosophy of fire and are allied with humans. It explores the grand themes of family, faith, and survival.
This article discusses the Easter eggs and homages in Zootopia 2 that you may have discovered. The main content includes: character and archetype Easter eggs, cinematic universe crossover Easter eggs, animal ecology and behavior references, symbol and metaphor Easter eggs, social satire and brand allusions, and emotional storylines and sequel foreshadowing.
[Zootopia Character Relationship Chart] The idealistic rabbit police officer Judy and the cynical fox conman Nick form a charmingly contrasting duo, rising from street hustlers to become Zootopia police officers!
blood
Post-donation processing and storage
Before donating blood: add anticoagulant
Blood donation site: simple blood type measurement
After donating blood: intelligent detection of blood type and source of infection
Centrifugal separation
Red blood cells/white blood cells/platelets/plasma have different storage conditions and clinical significance.
Plasma: 37 degrees for 5 days (continuous mixing and storage); refrigerated/frozen for longer
Red blood cells: After passing through the white blood cell filter and adding a protective agent, they can be stored for 42 days.
Platelets: Continuous horizontal storage at 22 degrees Celsius, 5 days
leukocyte
form
Large size, various shapes, high production rate and apoptosis rate (easy to be summoned quickly)
7-14 days lifespan
Normal value (10^9/L): 4~10
increase
Physiological increase: Pregnant women, newborns, after strenuous exercise, after bathing in cold/hot water, ultraviolet radiation, emotional excitement, etc.
Pathological increase: acute bacterial infection, severe tissue damage, poisoning, etc.
reduce
Viral infection, aplastic anemia, low immune function, or taking certain medications
Function
defense, protection
generation and regulation
Birth: Bone marrow (hematopoietic tissue)
Classified by structure
1. monocytes
Originates from bone marrow, enters blood circulation for 1 to 3 days, and reaches differentiation of various tissues.
Macrophages
Macrophages can survive in tissues for 3 months
Liver: Kupffer cells
Lung cancer: dust cells
Brain/Spinal Cord: Microglia
Attack anything considered foreign (first line of defense), contain lysosomes (phagocytosis)
During infection, inflammation, or tissue injury, they can follow chemotactic signals to migrate to damaged tissue/sites of inflammation, phagocytose pathogens and cellular debris, and digest them in phagolysosomes
Antigen presentation
Macrophages capture, endocytose, and express self or foreign antigens and present them to other immune cells
dendritic cells (DC)
The bridge between innate immunity and adaptive immunity
The commander of the human immune cell system, commanding various functions of the immune system
Tell helper T cells and B cells the characteristics of the cancer cells they have encountered
Multiple Cytokines that Sensitize Helper T Cells
Significantly stimulate the proliferation of naive T cells to activate quiescent naive T cells in the body
Macrophages and B cells can only stimulate activated or memory T cells.
The most powerful antigen-presenting cells (present antigens to T cells)
Macrophages: After receiving instruction signals, they are more likely to degrade engulfed cancer cells
Helper T cells: After receiving command signals, they are activated into cytotoxic T cells
Identify and kill cancer cells
converted into memory T cells
Natural killer cells: After receiving command signals, they directly attack cancer cells
2. Lymphocytes
Originates from the bone marrow, enters the blood circulation for 6 to 8 hours, enters the lymphoid tissue and survives for 4 to 5 days before aging and dying.
B cells
Release antibodies to assist T cell activation
T cells
Classified by function
Naive T-cell: T cells that have not been stimulated by antigen and have not yet matured.
Assists humoral and cellular immunity
T helper cells (Th): CD4 T cells, including Th0 (unactivated initial CD4 T cells), Th1, Th2, Th9, Th17, Th22, Tfh, etc.
Th0: non-activated naive CD4 T cells
Th1, Th2, Th9, Th17, Th22, Tfh, etc.
The main surface marker of helper T cells is CD4. T cells regulate or "help" other lymphocytes to function. They are known target cells for HIV and are drastically reduced during the onset of AIDS
Effectro T-cell: stimulated by antigens, proliferate and differentiate, and become T cells that can perform effector functions.
Cytokine release, cell killing, etc.
Memory T-cell:
After antigen stimulation, cells proliferate and differentiate to form cells that can survive for a long time and can mediate re-immunization. However, no very specific surface markers have been found on the surface of memory T cells.
Regulatory/Suppressor T-cell (Ts)
It usually plays an important role in maintaining self-tolerance and preventing excessive immune response from damaging the body. There are many types of regulatory/suppressor T cells, and the most actively studied ones are CD25 and CD4 T cells.
Cytotoxic T-cell:
Destroy infected cells. These cells function like a "killer" or cytotoxin in that they kill target cells that produce a specific antigen response. The main surface marker of cytotoxic T cells is CD8, also known as killer T cells.
Natural killer cells (NK)
Unique: Recognizes stressed cells in the absence of antibodies and MHC
Immune response is faster
Primary targets: viral infection and tumor cells
3. Granulocytes
Neutrophils (most abundant)
Originates from bone marrow, enters blood circulation and enters tissues within 6 to 8 hours
It will age and die after surviving 4 to 5 days in the tissue.
Present antigen to T cells
When deactivated: Spherical
When active: Amorphous
When bacteria invade, neutrophils exude from the capillaries to the inflammatory area under the action of chemotactic substances and use the plasma membrane to engulf the bacteria.
The nucleus is lobulated and has strong deformation, migration and phagocytosis capabilities.
Neutrophils contain a large amount of lysosomal enzymes, so they can break down bacteria and tissue debris that have been engulfed into the cells.
Invading bacteria are enclosed in a local area and eliminated, preventing the spread of pathogenic microorganisms in the body
When neutrophils themselves disintegrate, they release various lysosomal enzymes that can dissolve surrounding tissue and form an abscess.
Once in the tissue it does not return to the bloodstream
eosinophils
It originates from the bone marrow, enters the blood circulation, and is updated periodically during the day and night (6 to 12 hours): the number of cells decreases in the morning and increases at midnight. Can survive in tissue for 8-12 days
Survival in tissue for 8~12 days
Regulate allergic reactions
It can release prostaglandin E and inhibit the synthesis of basophils, and release histamine, leukotrienes and other biologically active substances released by enzymes such as histamine and aromatic sulfatase to inactivate basophils.
Attack parasites (worms, etc.)
The cytoplasm contains large eosinophilic granules, most of which are found in tissues (the number is 100 times that in blood)
Eosinophils have weak phagocytic ability
basophils
Originates from bone marrow and has short blood circulation time
Survival in tissue for 12~15 days
The cytoplasm contains larger alkaline staining granules
After being activated, it can release active substances such as heparin, histamine, and leukotrienes, which can enhance capillary permeability and cause local congestion and edema. It is an important effector cell involved in allergic reactions.
platelets
form
Small size, no nucleus, irregular
No core, no regulation, lifespan is only 7-14 days
Normal value (10^9 pieces/L): 100~300
Thrombocytopenia
Aplastic anemia, acute leukemia, hypersplenism, etc.
hemophilia
thrombocytosis
Bleeding, hemolysis, chronic myelogenous leukemia, inflammation, iron deficiency anemia, etc.
thrombus
Function
Hemostasis, coagulation
red blood cells
form
Small size, biconcave disc shape, mature RBC without nucleus
No core, no regulation, lifespan is only 120 days
Normal value (10^9/L): 5000 (male); 4200 (female)
RBC decrease
Anemia (pale complexion, dizziness, weight loss)
Physiological reduction
Growth and development too fast
Pathological reduction
Various anemias
Increased RBCs
Pathological increase
dehydration (continuous diarrhea or vomiting), extensive burns, or certain tumors
Polycythemia vera (whole bone marrow hyperplasia)
Myelofibrosis and bone marrow failure (10%)
Acute leukemia (1%)
RBC production consumes iron, leading to iron deficiency and smaller cells.
microcytosis
Increased blood volume and red blood cell count can lead to increased blood viscosity
thrombus
Stroke, myocardial infarction, etc.
secondary erythrocytosis
Smoking, use of androgenic steroids, etc. leading to tissue hypoxia
Detection
arterial oxygen saturation
Serum erythropoietin level (EPO)
P50 (oxygen partial pressure when hemoglobin oxygen saturation is 50%)
Normal results rule out polycythemia caused by high-affinity hemoglobinopathies (familial abnormalities)
Physiological increase
Excessive sweating, not drinking water for a long time, altitude sickness (increased red blood cells, improving HB's ability to transport oxygen)
Function
HB is fickle and transports oxygen
High oxygen binding, low oxygen release
Prefer carbon monoxide (gas poisoning)
generation and regulation
Birth: Bone marrow (hematopoietic tissue)
They grow into reticulocytes in 7 days. When they leave the bone marrow, they put on work clothes and mature, reaching the blood circulation.
Iron, VB12, folic acid and other nutrients (ingestion)
mature red blood cells
Hemoglobin (90%)
Four globin polypeptide chains
Four hemes
Take oxygen to the lungs
Unload oxygen to tissues
Traveling lightly (no nuclei or organelles) can transport more oxygen
Unable to produce structural proteins and repair proteins
Early death (120 days life span)
Live in a spleen or liver nursing home when your end is near
Macrophages take care of things
Recover globin and degrade it into amino acids: enter the blood for reuse
Recycle heme and degrade it into bilirubin and iron
Iron: Enters the blood and binds to transferrin in the plasma (recycled and reused)
Part of it will return to the bone marrow and continue to be used as raw materials.
Bilirubin: Enters the liver and detoxifies into conjugated erythrin
Excreted with bile
Filtered by the glomerulus and excreted in urine
kidney
After sensing the drop in oxygen content, EPO is secreted into the blood
EPO reaches the bone marrow and promotes the production of RBCs
Androgens: also promote the secretion of EPO by the kidneys (men are more powerful)
Athletes who take androgens or EPO-containing stimulants will be banned from competition
Individuals with kidney failure: unable to secrete sufficient amounts of EPO
severe anemia
plasma
Component
Water (90%, carries blood cells)
Intercellular substance equivalent to connective tissue
plasma proteins
albumin
Globulin: α1, α2, β and γ globulins
Gamma globulin has enzymatic activity and is also involved in the formation of antibodies
Fibrinogen: involved in blood clotting
electrolyte
The cations are mainly sodium ions and the anions are mainly chloride ions.
organic matter
Nutrients (amino acids, glucose, vitamins, fatty acids, minerals); hormones, enzymes; metabolic wastes
Physical and chemical properties
Specific gravity (1.025~1.030); viscosity (1.6~2.4, related to plasma protein content)
Osmotic pressure (313 Osm)
The osmotic pressure of 1mol/L NaCl is 2 Osm
electrolyte
PH value (7.35~7.45)
Plasma buffer pairs: sodium bicarbonate/carbonic acid; sodium bicarbonate/sodium dihydrogen phosphate; protein/protein sodium salt
Red blood cell buffer pair: HB/HB-K
Maintain plasma pH within a narrow range
Plasma will coagulate again when calcium ions are added
Reason: There is no free calcium ion in plasma and it contains fibrinogen
Function
Deliver nutrients and metabolic substances
Excrete metabolic waste
Filtered by the kidneys and excreted in the urine (urea, uric acid, creatinine)
Biochemical tests
blood sugar
Normal value (mmol/L): fasting is 3.92~6.16; after meal is 5.1~7.0
rise
Physiologically elevated
Within 2 hours after a meal (or injecting glucose); Emotional stress secretes epinephrine (or injecting epinephrine)
Pathologically elevated
Various types of diabetes, chronic pancreatitis, myocardial infarction, hyperthyroidism, hyperadrenaline function, intracranial hemorrhage, etc.
decline
Physiological decline
Hungry, strenuous exercise, after insulin injection, pregnancy, breastfeeding and taking hypoglycemic drugs
Pathological decline
Islet cell tumor, abnormal glucose metabolism, severe liver disease, hypopituitarism, adrenal insufficiency, hypothyroidism, long-term malnutrition, excessive insulin injection, etc.
blood lipids
Triglycerides
Lipids ((phospholipids, glycolipids, sterols, steroids)
liver function
Elevated serum alanine aminotransferase
Acute/chronic hepatitis, drug-induced liver injury, fatty liver, cirrhosis, etc.
Elevated serum aspartate amino acid transferase
Mid-stage myocardial infarction, toxic hepatitis, etc.
Tumor markers
PSAs
prostate cancer
AFP
Liver cancer, ovarian cancer, gastric cancer, pancreatic cancer, etc.
CA15-3
breast cancer important antigens
CA19-9
Pancreatic cancer, acute cholecystitis, liver cirrhosis, etc.