MindMap Gallery Otolaryngology, Head and Neck Surgery--Laryngology 003
Otolaryngology, Head and Neck Surgery - Introduces knowledge points about laryngeal inflammation, laryngeal tumors, and other laryngeal diseases. It’s full of useful information, interested friends can refer to it!
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The ice hockey schedule for the Milano Cortina 2026 Winter Olympics, featuring preliminary rounds, quarterfinals, and medal matches for both men's and women's tournaments from February 5–22. All game times are listed in Eastern Standard Time (EST).
This Valentine's Day brand marketing handbook provides businesses with five practical models, covering everything from creating offline experiences to driving online engagement. Whether you're a shopping mall, restaurant, or online brand, you'll find a suitable strategy: each model includes clear objectives and industry-specific guidelines, helping brands transform traffic into real sales and lasting emotional connections during this romantic season.
This Valentine's Day map illustrates love through 30 romantic possibilities, from the vintage charm of "handwritten love letters" to the urban landscape of "rooftop sunsets," from the tactile experience of a "pottery workshop" to the leisurely moments of "wine tasting at a vineyard"—offering a unique sense of occasion for every couple. Whether it's cozy, experiential, or luxurious, love always finds the most fitting expression. May you all find the perfect atmosphere for your love story.
The ice hockey schedule for the Milano Cortina 2026 Winter Olympics, featuring preliminary rounds, quarterfinals, and medal matches for both men's and women's tournaments from February 5–22. All game times are listed in Eastern Standard Time (EST).
Otolaryngology, Head and Neck Surgery--Laryngology 003
Chapter 6 Laryngeal Inflammation
Section 1 Acute inflammatory diseases of the larynx
1. Acute epiglottitis
【Classification】
Attention should be paid to tracheotomy: emergency tracheotomy or cricothyrotomy should be performed immediately when symptoms such as restlessness, cyanosis, triple concavity sign, disappearance of lung breath sounds, syncope, and shock occur.
2. Acute laryngitis/acute catarrhal laryngitis
[Cause] Infection (main), harmful gases, occupational factors, throat trauma, excessive smoking and alcohol, etc.
[Clinical manifestations] It can occur alone or secondary to acute rhinitis and pharyngitis (part of upper respiratory tract infection)
symptom
Hoarseness: main symptom; often appears suddenly
Throat pain: usually mild, but worse when speaking
Increased throat secretions: initially dry cough, sore throat when coughing; later it becomes thick secretions that are difficult to cough up
Systemic symptoms: milder in adults but more severe in children, including chills, fever, fatigue, and loss of appetite
Symptoms of nasopharyngeal inflammation
examine
Laryngoscopy: The lesions are bilaterally symmetrical and diffusely distributed; in the early stage, the surface of the vocal cords is congested, and when the subglottic mucosa is obviously red and swollen, it may appear like a "double vocal cord" under the vocal cords, and the glottis is incompletely closed during phonation; later, it may be purulent. Secretion attachment
[Differential diagnosis] Laryngeal tuberculosis, measles laryngitis
【treat】
3. Acute laryngitis in children
[Cause] Often secondary to acute rhinitis/pharyngitis, mostly caused by viruses (especially parainfluenza virus)
[Pathology] Mainly occurs in the subglottic space; dyspnea is prone to occur: ① Children's laryngeal cavity is small, laryngeal mucosa is loose, and swelling can easily cause glottis obstruction; ② Laryngeal cartilage is soft, mucosa and submucosa are loosely attached, and swelling occurs when inflammation occurs Severe; ③ The submucosal lymphatic tissue and glandular tissue of the larynx are rich, and submucosal swelling is easy to occur during inflammation, which narrows the throat cavity; ④ Children have poor cough reflexes, and secretions are difficult to discharge; ⑤ Children have poor resistance and immunity to infection The strength is not as strong as that of adults, and the inflammatory reaction is more severe; ⑥The nervous system of children is relatively unstable and is easily irritated and causes laryngospasm; ⑦Laryngospasm not only causes laryngeal obstruction, but also aggravates congestion.
[Clinical manifestations]
symptom
The onset is acute, often with fever; it manifests as paroxysmal barking cough, difficulty breathing, and hoarseness, followed by coughing up sticky sputum; persistent laryngeal obstruction symptoms (such as croup cough, aspiration, etc.) may occur after repeated attacks. Breathing stridor); in severe cases, there may be obvious three-sag sign, cyanosis, irritability, and respiratory weakness, until respiratory and circulatory failure and death.
examine
Laryngoscope: subglottic mucosa edema, severe cases may have ulcers
【Differential Diagnosis】
1. Foreign bodies in the trachea: Many have a history of inhalation of foreign bodies, followed by choking, severe coughing, inspiratory dyspnea, and cyanosis; check the chest and lungs for corresponding signs.
2. Laryngeal spasm in children: laryngeal stridor during inhalation, with a sharp and thin tone. The attack lasts for a short time. The symptoms may disappear suddenly without hoarseness.
3. Congenital laryngeal diseases: laryngoscopy
4. Others: throat manifestations of diphtheria, measles, chickenpox, whooping cough, scarlet fever, and mumps.
【treat】
Section 2 Chronic non-specific inflammation of the larynx
1. Chronic laryngitis
(1) Chronic simple laryngitis
[Cause] Spread of inflammation in adjacent parts, breathing through the mouth, inhalation of harmful gases, gastroesophageal reflux, Hp infection, excessive voice use, systemic diseases
[Clinical manifestations] More common in adults
symptom
Hoarseness: main symptom; initially intermittent, gradually becoming persistent; when the cricoarytenoid joints are involved, the hoarseness becomes more serious after waking up in the morning or after the vocal cords have rested for a long time
Mild pain, tightness, foreign body sensation in throat, accompanied by dry cough
examine
Laryngoscope: The laryngeal mucosa is diffusely congested, and thick secretions can be seen on the surface; the vocal cords are light red, and small dilated blood vessels can be seen on the surface parallel to the free edge of the vocal cords. The pronunciation is weak, the vibration is uncoordinated, and both sides are not closed well.
Electroglottogram (EGG): closed phase lengthened, open phase shortened
Dynamic laryngoscopy: the amplitude, mucosal wave, and vibration closed phase can be enhanced when the vocal cords are edema, and the symmetry and periodicity are uncertain.
[Treatment] ① Cause treatment: Treat peripheral inflammation, anti-reflux, and change bad living habits; ② Local anti-inflammatory drugs; ③ Physical therapy; ④ Oxygen/ultrasonic atomization inhalation, antibiotics and dexamethasone if necessary; ⑤ Voice correction
(2) Chronic atrophic laryngitis/dry laryngitis/ozena of larynx
[Cause] Primary, secondary (induced by atrophic rhinitis, atrophic pharyngitis, throat radiotherapy, etc.)
[Clinical manifestations] More common in middle-aged and elderly women
symptom
Dryness and discomfort in the throat, foreign body sensation, and swelling and pain
Hoarseness: worse in the morning (∵ pus and scab remain)
Paroxysmal cough: thick secretions and scabs are the main reasons; the scabs coughed up have blood streaks and odor; the hoarseness improves after coughing, but the sore throat often worsens
examine
Laryngoscope: Chronic congestion and dryness of the laryngeal mucosa, widening of the laryngeal cavity, yellow-green pus scab often covering the back end of the vocal cords, interarytenoid area, laryngeal ventricular zone, etc. After removal, the laryngeal mucosa appears dark red, dry and shiny like wax. When the internal laryngeal muscles atrophy, the vocal cords become thinner, looser and weaker, and both sides are incompletely closed during pronunciation.
EGG: shortened closed phase/no closed phase, shorter wave peak
[Treatment] Oral potassium iodide/ammonium chloride (stimulates laryngeal mucus secretion), steam atomization, oral vitamins; if there is scab attached, it can be removed after humidification under a laryngoscope
(3) Chronic hyperplasic laryngitis
[Features] May be related to GERD
[Clinical manifestations]
symptom
Similar to chronic simple laryngitis, but with heavier hoarseness and lighter cough
examine
Laryngoscopy: The laryngeal mucosa is extensively thickened, and the central part of the interarytenoid area is bulged/wrinkled, often with thick mucus accumulation; the vocal cords are congested, the edges are thickened, and the surface is nodular; the ventricular belt is also often hypertrophic and can still cover the vocal cords.
EGG: The closed phase is extended and the open phase is shortened.
Dynamic laryngoscope: poor symmetry and periodicity, disappearance of amplitude and mucosal waves in severe cases, poor vocal cord closure
[Treatment] Similar to chronic simple laryngitis; in severe cases, part of the hypertrophic tissue can be surgically removed
2. Polyp of larynx
[Pathology] Most of them are polyps of vocal cord; the elastic fibers and reticular fibers of the lamina propria of the mucosa are destroyed; they are divided into hemorrhagic type, hyaline deformation, edema type, and fibrous type under light microscope; and they are divided into colloid type under electron microscope. , telangiectasia
[Clinical manifestations]
symptom
The main manifestation is hoarseness; the size of the polyps has nothing to do with the fundamental frequency of pronunciation, but is related to rough sound quality; those with huge polyps located between the vocal cords on both sides may completely lose their voice, and may even have dyspnea and stridor; polyps hang down in the subglottic cavity Can irritate and cause coughing
examine
Laryngoscope: Smooth, translucent, drop-shaped new organisms with pedicles were seen in the front and middle part of the free edge of the vocal cord, mostly gray/light red, mostly unilateral.
Diagram: The former position shows more noise components mixed in the harmonics above 1000Hz; the latter position shows similar to vocal cord nodules
EGG: Notches can appear in different parts of the body
Dynamic laryngoscope: poor periodicity, symmetry, amplitude, mucosal wave weakening/disappearing, vibration off-phase weakening
[Treatment] Surgical resection is the main method, supplemented by glucocorticoids, antibiotics, and ultrasonic atomization treatment; resected polyps should be routinely sent for pathological examination.
3. Vocal nodules
[Pathology] It is more common at the junction of the anterior and middle 1/3 of the free edge of the vocal cord; it also occurs in children as screamer's nodule; it is mainly caused by localized acanthocyte hyperplasia of mucosal epithelium and hyperkeratosis/incomplete keratosis of the epithelial surface. secondary fibroplasia
[Clinical manifestations]
symptom
Early stage: vocal fatigue, intermittent hoarseness (occurs whenever high-pitched sounds are produced)
Progressive stage: hoarseness worsens (persistent, also occurs when speaking at a low pitch)
examine
Laryngoscope: There is a small nodule-like protrusion at the junction of the anterior and middle 1/3 of the free edge of the vocal cord, which is generally symmetrical on both sides.
[Treatment] ① Pay attention to vocal cord rest: If the nodules have not become significantly smaller after 2 to 3 weeks, other treatments can be taken; ② Pronunciation training; ③ Surgical resection: It is suitable for those who are irreversible, large, and have obvious hoarseness symptoms. In children, many nodules can be Natural disappearance of puberty
Chapter 7 Laryngeal Tumors
Section 1 Benign tumors of the larynx
1. Papilloma of larynx (most common)
[Pathology] Children often have multiple lesions, grow quickly and are prone to recurrence; adults often have single lesions and have a tendency to become malignant.
[Clinical manifestations]
symptom
Adult type: develops slowly, often characterized by progressive hoarseness, cough, laryngeal stridor, and dyspnea
Childhood type: develops quickly, often manifests as progressive hoarseness, and is prone to laryngeal obstruction
examine
Laryngoscopy: The tumor is pale/dark red, papillary on the surface, broad-based in children and often pedunculated in adults. It can occur in the vocal cords, ventricular cord, subglottic area, and can also spread to the hypopharynx and trachea.
[Treatment] CO2 laser removal of tumors under support laryngoscope is the most effective treatment method
2. Laryngeal hemangioma (hemangioma of larynx)
[Characteristics] Including capillary hemangioma (common) and cavernous hemangioma; symptoms are often not obvious, including hoarseness, difficulty breathing, and bleeding; asymptomatic patients may not be treated temporarily
3. Laryngeal fibroma (fibroma of larynx)
[Characteristics] The main manifestation is hoarseness, which develops slowly and generally does not become malignant; surgical resection is an effective treatment method.
4. Neurofibroma of larynx
[Characteristics] Often accompanied by systemic neurofibromas; tumors originate from the nerve sheath; the main symptoms are hoarseness, cough, and dyspnea; tumors are mostly located in the aryepiglottic folds or protrude into the pyriform fossa; surgical resection is an effective treatment method
Section 2 Laryngeal Cancer (carcinoma of larynx)
【pathology】
1. About 98% are squamous cell carcinomas, with glottis carcinoma being the most common (60%), followed by supraglottic carcinoma, and subglottic carcinoma being extremely rare; generally The morphology can be divided into ulcer-infiltrating type, cauliflower type, nodule/mass type, and mixed type.
2. Precancerous lesions: laryngeal papilloma, vocal cord leukoplakia
3. Diffusion transfer
[Clinical manifestations]
Typical manifestations include hoarseness, dyspnea, cough, dysphagia, and cervical lymph node metastasis
[Diagnosis] Anyone over 40 years old with hoarseness lasting more than 2 weeks, who does not improve after vocal rest and general treatment, should be carefully examined with a laryngoscope (pay special attention to the laryngeal surface of the epiglottis, anterior commissure, laryngeal ventricle and subglottic area, etc.) site); suspicious lesions can be confirmed by biopsy; enhanced CT helps to understand the scope of infiltration
【Differential Diagnosis】
1. Laryngeal tuberculosis: sore throat and hoarseness; laryngoscopy shows pale and edematous laryngeal mucosa, accompanied by multiple superficial ulcers, and the lesions are mostly located in the back of the larynx; lung lesions can be seen on X-ray; sputum Mycobacterium tuberculosis examination is helpful for diagnosis; Biopsy confirms diagnosis
2. Laryngeal syphilis: hoarseness; examination shows syphilitic nodules, deep ulcers, and laryngeal deformity after healing; serology and biopsy can confirm the diagnosis
3. Laryngeal papilloma: hoarseness; the tumor is papillary and can be diagnosed by biopsy
4. Laryngeal amyloidosis: hoarseness; examination shows a dark red mass with a smooth surface, and biopsy can confirm the diagnosis.
[Treatment] A single method can be used to treat the early stage. Comprehensive treatment with surgery as the mainstay is recommended for those with intermediate or advanced stage/relapse.
Surgical treatment
Principle: Preserve/reconstruct laryngeal function as much as possible under the premise of complete tumor resection.
technique
Partial laryngectomy: such as CO2 laser surgery, vertical partial laryngectomy, etc.
①Total laryngectomy: ① Not suitable for local resection due to the scope of the tumor/the patient's general condition and other reasons; ②Failure of radiotherapy and recurrence after partial resection; ③T4 stage involving and penetrating cartilage; ④Primary subglottic cancer; ⑤After radiotherapy Radiation osteomyelitis or poor laryngeal function after partial resection is difficult to correct; ⑥ Laryngeal function cannot be preserved in laryngopharyngeal cancer
Neck lymph node dissection: especially supraglottic cancer; even for N0 supraglottic cancer, segmented neck lymph node dissection should be performed
Postoperative functional reconstruction and speech rehabilitation: esophageal articulation, artificial larynx, etc.
Radiation Therapy
Radiotherapy alone: ① early-stage vocal cord cancer, which does not involve the anterior commissure forward and does not involve the vocal cord process backward, and the vocal cords move well; ② supraglottic cancer located at the free edge of the epiglottis and relatively localized; ③ poor general condition, not suitable for surgery; ④ late stage Tumor, not suitable for surgery
Preoperative radiotherapy: suitable for patients with wide range of lesions, involving the laryngopharynx and poor differentiation
Postoperative radiotherapy: ① The primary tumor has invaded the soft tissues outside the larynx and neck; ② Multiple cervical lymph nodes have metastasized and the tumor has penetrated the lymph node capsule; ③ The surgical resection margin is very close to the tumor margin (<5mm) or pathologically confirmed that the resection margin is residual tumor
Other treatments
Chemotherapy: not very sensitive; but concurrent chemoradiotherapy for advanced laryngeal cancer can improve the rate of laryngeal preservation.
Biological therapy: especially EGFR monoclonal antibodies
Chapter 8 Other diseases of the larynx
1. Laryngeal edema (edema of the larynx)
【Cause】
Infectious
Specific infection, non-specific infection
non-infectious
Trauma, angioedema, allergies, systemic diseases (heart disease, nephritis, cirrhosis, hypothyroidism)
[Clinical manifestations] Hoarseness, slurred speech, and throat obstruction; hereditary angioedema is characterized by onset within a few hours and usually gradually subsides after 72 hours; laryngoscopy: Infectious laryngeal edema shows extensive redness and swelling of the mucosa with secretions; Non-infectious laryngeal edema may show pale mucosal edema
【Treatment】Relieve the obstruction first, then treat the cause
2. Keratosis of larynx and leukoplakia of larynx
3. Laryngeal amyloidosis/amyloidoma
[Pathology] It is more common in around 40 years old, and is more common in the ventricular zone; under light microscopy, amyloid is an amorphous substance containing eosinophilic substances and lymphocyte infiltration; under electron microscopy, fibrils and pentagonal rod-shaped substances can be seen; divided into primary Type, secondary type, type with MM, genetic familial type
[Clinical manifestations]
symptom
Symptoms vary depending on the location; they are often characterized by foreign body sensation, irritating cough, hoarseness, and labored breathing; they are slowly progressive.
examine
Laryngoscope: The lesion is thickened, raised, and lumpy, and the mucosa is smooth and normal in color.
Patients with diffuse disease should undergo systemic examination
Imaging, pathological tissue biopsy (sections stained with Congo red)
[Treatment] Surgical resection, laser treatment, corticosteroids