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MindMap Gallery Pharmacology 9th Edition Chapter 9 Choline Receptor Blocking Drugs (II)—N Choline Receptor Blocking Drugs

Pharmacology 9th Edition Chapter 9 Choline Receptor Blocking Drugs (II)—N Choline Receptor Blocking Drugs

About pharmacology-N choline receptor blocking drugs mind map, including ganglion blocking drugs, Skeletal muscle relaxants, etc.

Edited at 2023-12-04 12:09:16

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Pharmacology 9th Edition Chapter 9 Choline Receptor Blocking Drugs (II)—N Choline Receptor Blocking Drugs

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Outline

Chapter 9 Choline Receptor Blocking Drugs (II)—N Choline Receptor Blocking Drugs

Overview: Nn choline receptor blocking drugs block ganglion Nn receptors and Nm choline receptor blocking drugs block Nm receptors on motor endplates.

Section 1 Ganglion Blocking Drugs

Overview: Also known as Nn choline receptor blocking drugs. It can bind to the Nn choline receptor in the ganglion and competitively block the binding of ACh to its receptor, so that ACh cannot cause depolarization of ganglion cells, thereby blocking the transmission of nerve impulses in the ganglion.

Section 2 Skeletal muscle relaxants

Overview: Also known as Nm choline receptor blockers or neuromuscular blocking drugs

1. Depolarizing muscle relaxants

Mechanism of action: The drug has a strong affinity with the N2 receptor on the posterior membrane of the neuromuscular junction, and is not easily decomposed by cholinesterase, resulting in a depolarization effect similar to ACh but longer lasting, making the N2 in the posterior membrane insensitive to ACh. Relaxation of skeletal muscles. First, phase I is blocked (depolarized), then phase II is blocked (non-depolarized).

Functional characteristics

1. Short-term fasciculations often occur at the beginning of drug effects.

2. Rapid tolerance

3. Anticholinesterase drugs not only fail to antagonize its effect, but enhance it (for example, neostigmine can inhibit AChE and reduce the metabolism of succinylcholine)

4. The therapeutic dose has no ganglion blocking effect

Classic Drug: Succinylcholine

2. Non-depolar muscle relaxants

Overview: Also known as competitive muscle relaxants

Mechanism of action: This type of drug can compete with ACh for N2 choline receptors at the neuromuscular junction, but does not excite the receptors. It can competitively block the depolarization effect of ACh and relax muscles.

Functional characteristics

1. No stimulating effect on skeletal muscles

2. Can be enhanced by similar muscle relaxants

3. AChE inhibitors can antagonize its muscle relaxant effect

4. It has certain ganglion blocking effect and histamine releasing effect.

Classic drug: tubocurarine