Neurobiology-Choline Receptors

This is a mind map about neurobiology-choline receptors. Choline receptors are divided into M receptors and N receptor. Hope it helps everyone.

Edited at 2023-12-03 20:36:48

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Neurobiology-Choline Receptors

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Outline

Detailed properties and mechanisms of action of major neurotransmitters
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choline receptor

M receptor

Choline esters

acetylcholine

Cardiovascular System

relax blood vessels

weaken myocardial contractility

slow heart rate

Slows down atrioventricular node and Purkinje fiber conduction

Shorten the atrial refractory period

Exciting gastrointestinal tract

Excites urinary tract smooth muscle

other

Glands: Increased secretion of glands, such as sweat glands and salivary glands

Eyes: pupillary sphincter contraction, pupil constriction, ciliary muscle contraction

Ganglia and skeletal muscles: Causes sympathetic and parasympathetic nerve excitement and skeletal muscle contraction

Bronchial tubes: constriction of bronchi

Central nervous system: There are choline receptors in the central nervous system, but because acetylcholine cannot easily pass through the blood-brain barrier, peripheral administration rarely has an effect.

methacholine

Because of the methyl group, acetylcholinesterase cannot hydrolyze it quickly, and its action time is longer than ACh. Contraindications: Patients with bronchial asthma, coronary ischemia, ulcer disease

carbachol

It has a longer action time than ACh and has agonistic effects on M and N receptors. It is only used for subcutaneous injection and intravenous injection is prohibited. It has many side effects. Atropine has a poor interpretation effect on it. It is used to treat glaucoma. The contraindications are the same as methacholine.

becholine

Not easy to hydrolyze, relatively selective for M-choline, contraindications are the same as methacholine

Cholinomimetic alkaloids

Pilocarpine

Miosis: activates M choline receptors in the pupillary sphincter

Reduce intraocular pressure

Regulate spasm

Increase the secretion of sweat and salivary glands

Muscarine

Symptoms of poisoning: tearing, nausea, vomiting, headache, visual disturbance, abdominal cramps, diarrhea, bronchospasm, bradycardia, drop in blood pressure, shock, which can be treated with atropine

N receptor

Distribution and skeletal muscle

Distribution: Sympathetic ganglia, parasympathetic ganglia, adrenal medulla

Nicotine

Liquid alkaloids, highly fat-soluble, absorbed through the skin, have bidirectional effects on ganglion Nn choline receptors. They briefly excite Nn receptors at the beginning of use, and then continue to inhibit Nn receptors.