The brain concentration is greater than the plasma concentration. It is mainly excreted through liver metabolism and kidneys. It is highly fat-soluble and easily accumulated in adipose tissue. The individual dosage varies greatly.

Mainly antagonizes dopamine in the limbic system of the brain, and can also antagonize alpha receptors and M receptors

Central Nervous System

autonomic nervous system

Effects on the endocrine system

Treat mental illness

Antiemetic and intractable hiccups

Hypothermic anesthesia and artificial hibernation

Common reactions

extrapyramidal reaction

Psychosis, convulsions, epilepsy

Allergic reactions: liver damage, jaundice, granulocytopenia, anemia

Cardiovascular and Endocrine: BP↓; Endocrine Disorders

Acute poisoning: lethargy, BP↓→shock, myocardial damage

1. Strong antipsychotic and antiemetic effects; strong extrapyramidal adverse reactions

2. Weak sedative and antihypertensive effects

1. Has anti-anxiety and anti-depressant effects

2. Mild adverse reactions

Suitable for obsessive-compulsive states or anxiety, depression, schizophrenia and menopausal depression.

1. Strong antipsychotic effects, antiemetic effects, and extrapyramidal reactions

2. Weak sedative and antihypertensive effects

Commonly used for various types of schizophrenia and mania, and also suitable for antiemetics and persistent hiccups

Loss of pain, trance, indifference to the environment

Minor surgery, pre-anesthetic medication, controlling aggressive behavior of mental patients

The difluorobenzene derivative of droperidol has good anti-hallucination and delusion effects

It is clinically used to treat schizophrenia, mania and Tourette syndrome, and is contraindicated for heart disease.