After allogeneic stem cell transplantation

Mucosal squamous intraepithelial lymphocyte infiltration, basal vacuolation, squamous epithelial cell apoptosis and parakeratosis, necrosis when the disease is severe, and significant submucosal fibrosis is more common in chronic disease.

Strong acids and alkalis can cause inflammation and damage to the esophagus

Esophageal mucosal congestion, edema, necrosis and ulcer formation, followed by granulation tissue proliferation and scar formation

Intraepithelial lymphocyte infiltration (>20 cells/HPF), especially around the papilla of the lamina propria (50 to 55 cells/HPF), spongy layer edema, and few or no neutrophils and eosinophils in the lesion

Dense mononuclear cell infiltration and well-defined granulomas, especially when accompanied by mid-esophageal ulcers, flaccid ducts, or nodular lesions, should be highly suspicious of this disease. If caseous necrosis occurs, tuberculosis should be considered

Drugs adhere directly to

Esophageal mucosal congestion, edema, erosion, ulcers, and bleeding

Radiotherapy for thoracic and mediastinal malignant tumors

Acute injuries include mucosal and submucosal edema, necrosis, or ulceration. Chronic injuries include mucosal ulceration, submucosal fibrosis, telangiectasias, arteriolar wall thickening, and submucosal gland atrophy. Atypical epithelial cells and fibroblasts have relatively characteristic changes, with deeply stained and homogenized nuclei, large eosinophilic nucleoli, normal nucleocytoplasmic ratio, and no mitotic figures, which are reactive changes.

Eosinophils were seen in both proximal and distal mucosal epithelium, >15 cells/high-power field; Eosinophilic microabscess formation (aggregation of at least 4 eosinophils); superficial eosinophils; Eosinophil degranulation; Structural changes include intercellular edema (acanthoedema), basal hyperplasia, and nipple elongation

In some lesions, the inflammation is not obvious, and in mild cases, there is only congestion. Typical features may include epithelial damage, ranging from ballooning degeneration to mucosal shedding leading to erosion and ulceration; basal cell hyperplasia, exceeding 15% to 20% of the epithelial thickness; papillae of the lamina propria extending to 1/3 of the epithelium, and blood vessels Expansion; infiltration of intraepithelial lymphocytes, neutrophils, and eosinophils, and occasionally multinucleated squamous epithelial cells, similar to viral infection

The mucosal squamous epithelium showed varying degrees of atrophy and thinning, accompanied by parakeratosis and basal cell degeneration. Colloidal or Civatte bodies can be seen, which are transparent bodies formed after epithelial cell degeneration. Infiltration of band-like lymphocytes (mainly T cells) can be seen in the lamina propria of the mucosa