Poor oral effect

Difficult to enter the nervous system

Not easy to penetrate the cornea

Exciting skeletal muscles has powerful effects: (-)AChE ( )N2-R ( ) Motor nerve terminals release ACh

It has a strong effect on stimulating the smooth muscle of the gastrointestinal tract and bladder muscles, promoting exhaust and urination.

Depresses the heart: slows heart rate, decreases cardiac output

1. Myasthenia gravis: an autoimmune disease in which the body produces an immune response to its own Nm receptors on the postsynaptic motor end plate.

2. Abdominal bloating and urinary retention (mostly after surgery)

3. Detoxification of overdose of competitive neuromuscular blocking drugs

Expansion: Is neostigmine detoxification contraindicated in succinylcholine poisoning? Answer: Succinylcholine - hydrolysis by pseudocholinesterase - muscle relaxant effect Neostigmine – which inhibits cholinesterase – greatly prolongs its muscle relaxant effect

Opposite eyes: cholinergic receptor agonists. Conjunctival use of this class of drugs can cause conjunctival congestion and contraction of the pupillary sphincter and ciliary muscles located at the edge of the iris, resulting in miosis and ciliary muscle accommodation spasm.