Anti-schizophrenia effect

Antiemetic effect

thermoregulatory effect

Antagonizes α-adrenergic receptors, causing blood vessels to dilate and lower blood pressure, but is not suitable for the treatment of hypertension

Antagonizes M choline receptors, causing dry mouth, constipation, and blurred vision

Activates D2 subtype receptors in the nodule infundibulum system

Significant relief of positive symptoms

The treatment effect is good for acute patients, but the effect is poor for chronic patients.

Ineffective for patients with type 2 schizophrenia or even worsen their condition

It is effective for organic schizophrenia and symptomatic schizophrenia, but the dose must be small and the drug must be stopped immediately after the symptoms are controlled.

It has a significant anti-emetic effect on vomiting caused by drugs (digitalis, morphine, tetracycline) and diseases (uremia, malignant tumors)

Effective for stubborn hiccups

Not effective against motion sickness

Physical cooling combined with chlorpromazine can be used for hypothermic anesthesia

Chlorpromazine combined with pethidine, promethazine can be used for artificial hibernation

Artificial hibernation is mostly used for severe trauma. Adjuvant treatment for septic shock, febrile convulsions, central hyperthermia, and thyroid storm

Central depression symptoms

M receptor antagonist symptoms

a receptor antagonism

parkinsonism

akathisia

acute dystonia

A special and persistent movement disorder caused by long-term use of chlorpromazine. Involuntary stereotyped movements of the mouth and face, generalized choreathetosis, which do not disappear for a long time after drug withdrawal.

Mechanism: Dopamine receptors are antagonized for a long time, and receptor sensitivity increases or feedback promotes increased release of dopamine receptors in the presynaptic membrane.

Anticholinergic drugs worsen symptoms, anti-DA drugs reduce reactions

hyperprolactinemia

After taking a large amount at one time, drowsiness occurs, blood pressure drops to shock levels, and myocardial damage occurs.

Symptomatic treatment

Blocks the reuptake of NS and 5-HT in nerve terminals, increases the transmitter concentration in the synaptic gap, and promotes synaptic transmission function.

antidepressant effect

Blocks M choline receptors, manifesting as blurred vision, dry mouth, constipation, and urinary retention

Blocks a1 receptors, lowers blood pressure, and causes arrhythmias, among which tachycardia is more common.

block a1 receptor