MindMap Gallery Biochemical testing of bone metabolism
This is a mind map about biochemical testing of bone metabolism, including basic theories of bone metabolism, clinical applications of bone metabolism markers, etc.
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This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
Biochemical testing of bone metabolism
Basic theory of bone metabolism
composition of bone tissue
Interstitium (bone matrix)
Inorganic components
Calcium, Phosphorus, Magnesium
Sodium, potassium, zinc, manganese, etc.
organic ingredients
Collagen, non-collagen protein, proteoglycan, lipid, etc.
cell
bone cells
osteoblast
Mediates bone formation
Osteoclasts
Mediates bone resorption
bone metabolism
bone formation
bone alkaline phosphatase
Osteocalcin
Type I collagen carboxyl propeptide
bone resorption
tartrate-resistant acid phosphatase
Pyridinol and deoxypyridinol
Type I collagen carboxyl terminal peptide
Urinary hydroxyproline and hydroxylysine glycosides
dynamic equilibrium
Bone minerals (calcium, phosphorus and magnesium)
Hormone regulation
Active Vitamin D3, PTH and Calcitonin
Calcium and phosphorus metabolism regulation index
local regulator
Clinical application of bone metabolism markers
osteoporosis
primary osteoporosis
A degenerative disease that occurs with age Type I, also known as postmenopausal osteoporosis: usually occurs within 5-10 years after menopause; Type II senile osteoporosis: refers to osteoporosis that occurs after the age of 70.
Type I: Normal B-ALP, elevated bone resorption and bone formation markers
Type II: Normal B-ALP, decreased bone formation and bone resorption markers
secondary osteoporosis
Osteoporosis caused by factors such as other diseases or drugs
idiopathic osteoporosis
It is more common in teenagers, usually with a genetic history, and is more common in women (osteoporosis caused by female lactation and pregnancy is often included in this type of osteoporosis)
Osteomalacia and rickets
Laboratory tests: blood calcium is normal or decreased, and the decrease in blood phosphorus is more obvious; urinary calcium decreases; urinary phosphorus can be normal or increased; blood ALP increases, and the proportion of bone-derived ALP in ALP isoenzymes increases; blood PTH often increases; Reduced active vitamin D
Osteitis deformans
Also known as osteitis deformans or Pagets disease: increased osteoblasts
Laboratory tests: Increased serum ALP and B-ALP Urinary deoxypyridinol and hydroxyproline are increased; blood Ca, P, Mg and PTH are mostly normal: in large and stable Paget's disease, blood calcium can be significantly increased.
renal osteopathy
Category: 1. Osteitis fibrosis 2. Aluminum-related bone disease 3. Mixed osteodystrophy
Laboratory tests: blood calcium and phosphorus tests; alkaline phosphatase activity: significantly increased in advanced fibrous osteitis; 1,25(OH)2D3 level: decreased levels suggest vitamin D deficiency; blood parathyroid hormone: fibrous Increased osteitis
Determination and evaluation of bone metabolism markers