It is composed of significantly pleomorphic epithelioid cells and tumor giant cells, with poor cell adhesion, and phagocytosis can be seen in the tumor cells.

Positive for CK and Vimentin, CD68 and Syn can be expressed in a few cases

Analogous to undifferentiated nonkeratinizing carcinoma of the nasopharynx

Primarily differentiated cells are arranged in fuzzy nests with unclear cell boundaries. The nuclei are vacuolated and mitotic figures are easily visible. The interstitium is rich in lymphocytes and varying amounts of plasma cells. The cells are CK positive.

Barrett's esophagus: columnar metaplasia of the squamous epithelium at the lower end of the esophagus, an acquired lesion, which is a complication of gastroesophageal reflux disease. The esophagogastric junction is covered by at least 3cm of columnar epithelium and is called Barrett's esophagus.

Esophageal adenocarcinoma occurs on the basis of Barrett's esophagus; its morphology is similar to gastrointestinal adenocarcinoma; the adjacent Barrett's esophageal mucosal epithelium is often accompanied by varying degrees of dysplasia.

Usually positive for CK7 and CK19, positive for AMACR, negative for CK20, and positive for mucus stains (AB, PAS, mucus carmine)

adenoid cystic carcinoma

mucoepidermoid carcinoma

adenosquamous carcinoma

undifferentiated carcinoma

other

Grading (Principle: Cytological atypia, mitotic figures, and degree of keratinization)

Early infiltration manifestations: abnormal epithelial angles extend downward, with irregular or sharp borders, often manifesting as pushing infiltration and damaging infiltration.

1. Esophageal squamous cell carcinoma usually consists of moderately to well-differentiated cells, polygonal in shape, with visible intercellular bridges and keratinization; 2. Poor differentiation is rare and can be solid or sarcomatous; 3. Tumor cells occasionally display a Paget disease-like distribution;

basaloid squamous cell carcinoma

sarcomatoid carcinoma

verrucous carcinoma

low level

high-level