MindMap Gallery Ischemia-reperfusion injury mind map
This is a mind map about ischemia-reperfusion injury, including causes and conditions, mechanisms of occurrence, functional metabolic changes, and the pathogenesis basis of prevention and treatment.
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This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
ischemia reperfusion injury
Reasons and conditions
Common causes
Common conditions
ischemia time
collateral circulation
aerobic level
reperfusion conditions
The mechanism
Increased free radicals
Free radical concept and classification
Oxygen free radicals
lipid free radicals
Generation and removal of free radicals
generate
Single electron reduction during oxidative phosphorylation
Other reactions
enzymatic reaction
non-enzymatic reaction
Clear
Antioxidants
Antioxidase
Mechanism of free radical increase caused by ischemia-reperfusion
mitochondrial damage
Neutrophil recruitment and activation
Increased xanthine oxidase formation
Increased autooxidation of catecholamines
Increased free radicals cause damage to the body
membrane lipid peroxidation
Damage to cell membrane & organelle membrane structures
Increased bioactive substances
Reduced ATP production
protein function inhibition
Nucleic acid damage and DNA fragmentation
calcium overload
The mechanism of calcium overload caused by ischemia-reperfusion
Abnormal Na-Ca2 exchange
direct activation
indirect activation
PKC activation
biofilm damage
cell membrane damage
mitochondrial membrane damage
endoplasmic reticulum membrane damage
Mechanism of body damage caused by calcium overload
energy metabolism disorder
Decomposition of cell membrane and structural proteins
aggravate acidosis
Overactivation of inflammatory response
The mechanism of excessive activation of inflammatory response caused by ischemia-reperfusion
Increased production of cell adhesion molecules
Increased production of chemokines and cytokines
The mechanism by which inflammatory response causes damage to the body
Microvascular damage
Hemodynamic changes
increased permeability
cell damage
Functional metabolic changes
myocardial ischemia-reperfusion injury
reperfusion arrhythmia
Possible mechanism
Heterogeneity of action potential duration among reperfused myocardium
cardiac calcium overload
Free radicals alter cardiac muscle cell membranes
Effects of catecholamines
myocardial systolic dysfunction
reperfusion myocardial stunning
Microvascular obstruction
Structural changes in myocardium
Changes in cerebral ischemia-reperfusion injury
Excitatory amino acid toxic effects
Increased free radicals, reactive oxygen species and inflammatory mediators
calcium overload
Changes in ischemia-reperfusion injury of other organs
lung
liver
kidney
intestinal
The basis of disease prevention and treatment
Early restoration of blood flow and control of reperfusion conditions
Scavenge and reduce free radicals, reduce calcium overload
free radical scavenger
Reduce free radical production
Apply cytoprotective agents and inhibitors
Activate endogenous protective mechanisms
ischemic preconditioning
ischemic postconditioning
remote ischemic adaptation