MindMap Gallery Causes and prevention of high uric acid thought map
Mind map of causes and prevention of high uric acid, what is uric acid? What role does it play in the human body? What health problems can excessive uric acid cause? How should patients with high uric acid eat, exercise, and control uric acid levels in the blood? This brain map can help you answer them one by one. I hope it can help you!
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Causes and prevention of high uric acid
Introduction to uric acid
What is uric acid
Uric acid is the final metabolite of purine in the human body and can be excreted from the urine through the kidneys
Uric acid acts as an antioxidant in the blood to help fight against oxidative stress. At physiological concentrations, it has antioxidant, free radical scavenging, and neuroprotective effects.
In other mammals, uric acid is further broken down into allantoin by the action of uricase. During the evolution of humans, the gene encoding uricase became a silent gene, resulting in higher uric acid levels in the human body than in other mammals.
Mechanism of formation of uric acid
Uric acid is a metabolite of purine and is mainly metabolized through the small intestine, liver and kidneys
Source of purine: Purine in the human body exists in the form of nucleotides, which is obtained through food or produced by the catabolism of its own nucleic acids.
Uric acid formation pathway 1: adenine nucleotide - adenine - hypoxanthine - xanthine - uric acid
Formation path 2 of uric acid: guanine nucleotide - guanine - xanthine - uric acid
Purine mainly catalyzes the formation of uric acid in the small intestine and liver, and uric acid is excreted through the urine through filtration by the kidneys.
Dangers of high uric acid
The role of uric acid
Uric acid has certain positive effects in the human body. First of all, uric acid has an antioxidant effect, which can fight against free radical damage and protect cells from oxidative stress damage. Secondly, uric acid also has the function of improving intelligence, protecting the nervous system, and maintaining the normal function of the brain to a certain extent.
If there is no uric acid in human blood, it may weaken the body's antioxidant capacity and increase free radical damage, thus accelerating cell aging and disease. At the same time, the nervous system may be affected to a certain extent, and the normal function of the brain may be impaired.
normal levels of uric acid
Male blood uric acid level should be between 149 and 416 μmol/L
Women’s blood uric acid level should be between 89 and 357 μmol/L
Clinically, a condition in which blood uric acid exceeds the maximum range is called hyperuricemia.
Symptoms of hyperuricemia
gout
When the level of uric acid in the blood is too high, it will cause uric acid crystals to be deposited in the joints, causing acute gouty arthritis, which is manifested by symptoms such as redness, swelling, heat and pain in the joints. This is the most common symptom of high uric acid.
kidney damage
Hyperuricemia can lead to the deposition of uric acid crystals in the kidneys, leading to acute or chronic uric acid nephropathy, kidney stones, etc. In severe cases, it can lead to impaired renal function and symptoms such as hematuria, proteinuria, edema, and hypertension.
atherosclerosis
Hyperuricemia promotes the formation of atherosclerosis and increases the risk of cardiovascular disease
hypertension
Hyperuricemia has a certain correlation with the onset of hypertension and may increase the incidence of hypertension
Complications of hyperuricemia
diabetes
Hyperuricemia affects insulin secretion and utilization, thereby increasing the risk of diabetes
obesity
There is an interactive relationship between hyperuricemia and obesity. Patients with hyperuricemia are more likely to develop symptoms of obesity.
Hyperlipidemia
Patients with hyperuricemia often have symptoms of hyperlipidemia at the same time, and the two promote each other and increase the risk of cardiovascular disease.
Causes of high uric acid
Improper diet
Long-term intake of purine-rich foods, such as animal offal, beer, seafood, etc.
Abnormal purine metabolism
Disturbances in the metabolism of purine substances in the body
disease factors
Diseases such as polycythemia and myeloproliferative diseases can lead to increased decomposition of endogenous nucleic acids in the human body, leading to increased uric acid synthesis.
kidney disease
The kidney is an important organ for excretion of uric acid. If the kidney function is not good, it will lead to incomplete excretion of uric acid, which will lead to an increase in uric acid.
drug factors
Aspirin, diuretics and other drugs can inhibit the excretion of uric acid, leading to an increase in blood uric acid levels.
Prevention and treatment of high uric acid
diet modification
Reduce intake of high-purine foods
Animal offal: Duck liver, quail meat, pigeon meat, pig liver, beef liver, pig brain, pig kidney have high purine content and should be avoided or reduced as much as possible.
Seafood: caviar, fish roe, shark's fin, salmon, eel, caviar, shrimp, crab, shellfish. Patients with high uric acid should avoid or limit their intake. The purine content in these seafood is high, which may cause uric acid after ingestion. Elevated levels aggravate symptoms of high uric acid.
Soups: including various broths, fish soups, hot pot soups, etc. Due to the long cooking time, the purine content in soups is usually high, and patients with high uric acid should try to avoid or reduce their intake. These soups usually contain high amounts of purine, which may increase uric acid levels after being consumed, which is not good for the health of patients with high uric acid.
Alcoholic beverages: Beer, in particular, contains high levels of purine, and alcohol will inhibit the excretion of uric acid, further exacerbating the increase in uric acid. Patients with high uric acid should try to avoid or reduce their intake.
Some fish: such as anchovies, sardines, white hairtail, silver carp, dried small fish, etc. have high purine content and their intake should be controlled.
Meat: Duck, beef, pork, and mutton need to be eaten in moderation. Red meat has a higher purine content than white meat.
Soy products: such as tofu, dried beans, soy milk, etc., especially unprocessed soy products, have relatively high purine content. Made from soybeans, black beans, etc., these beans have higher purine content. However, in the process of making soy products, due to structural damage and dilution, the purine content usually decreases. Therefore, moderate intake of soy products will not have a major impact on uric acid levels. .
Mushrooms: In addition to mushrooms, other mushrooms such as shiitake mushrooms, enoki mushrooms, king oyster mushrooms, etc. also contain high purine. These mushroom foods are relatively high in purine, but when consumed in moderation, they usually do not have a significant impact on uric acid levels.
Some nuts: such as peanuts, cashews, almonds, hazelnuts, etc., also have high purine content. Although they are high in purine, eating them in moderation usually does not cause excessive increases in uric acid levels.
Although some vegetables: asparagus, mushrooms, mung bean sprouts, and peas contain a certain amount of purine, their purine content is relatively low, and moderate intake will not have a large impact on uric acid levels. Moreover, these foods are rich in other nutrients that contribute to good health
Eat more low-purine foods
Eggs: Eggs, duck eggs and other egg foods have low purine content and are rich in protein and other nutrients.
Dairy products: Milk, yogurt, cheese and other dairy products contain almost no purine and are rich in calcium and protein, which can be a good source of nutrition for patients with high uric acid.
Fresh fruits and vegetables: such as apples, pears, peaches, watermelons, grapes, spinach, celery, carrots, etc., which are rich in vitamins and minerals and have relatively low purine content
Drink more water: Drinking water helps with urination and reduces the concentration of uric acid in the blood
Exercise
Strengthen aerobic exercise
Promote uric acid excretion: Aerobic exercise can improve cardiopulmonary function and promote blood circulation, thereby helping to excrete uric acid. For patients with high uric acid, increasing uric acid excretion is an important way to reduce blood uric acid levels.
Improve body metabolism: Aerobic exercise can improve the body's overall metabolic function, including promoting fat burning and enhancing muscle strength. This helps reduce the burden on the body and improve related metabolic diseases such as obesity, thereby helping to reduce uric acid levels.
Regulate the endocrine system: Aerobic exercise also has a positive effect on regulating the endocrine system and can improve problems such as insulin resistance. Insulin resistance is one of the important factors leading to elevated uric acid, so improving insulin resistance through aerobic exercise can help reduce uric acid levels.
Carry out appropriate anaerobic exercise
Weight control
There is a strong relationship between obesity and high uric acid. Obese people have higher body fat content, and adipocytes release substances called adipokines. These adipokines affect the metabolism and excretion of uric acid, leading to increased uric acid levels. In addition, obesity can easily cause insulin resistance, which can reduce the excretion of uric acid by the kidneys, further exacerbating the increase in uric acid.
The reason why improving obesity is beneficial to reducing uric acid levels is that during the weight loss process, body fat is reduced and the adipokines released by adipocytes are also reduced, thereby reducing interference with uric acid metabolism and excretion. At the same time, the process of weight loss is usually accompanied by an improvement in diet and increased exercise. These factors also help to reduce uric acid levels. Improvement in dietary structure will reduce the intake of high-purine foods and reduce uric acid production; increasing exercise can promote uric acid excretion.
Quit smoking and limit alcohol
Cigarettes contain nicotine, which is converted into uric acid in the human body, which may increase uric acid levels in the body. The purine content in wine is also high, and long-term or heavy drinking may also lead to increased uric acid levels. Beer, in particular, has extremely high purine content, which is more likely to cause an increase in uric acid levels.