captopril, enalapril

Losartan, Valsartan

Sacubitril/valsartan

digoxin

Dopamine, dobutamine, milrinone

Attenuating AngII vasoconstrictor

Inhibit bradykinin degradation → expand blood vessels

Water-soluble ↑, prolonged action time

positive inotropic effect

Ca2⁺↑ in cardiomyocytes

Contraction ↑, increase cardiac output

Does not increase myocardial oxygen consumption

Treatment amount

Poisoned

Increase renal blood flow and glomerular filtration function

Heart failure with atrial fibrillation and rapid ventricular rate is best

It is effective in cardiac insufficiency caused by valvular disease, rheumatic heart disease (except cases of high-grade mitral stenosis), coronary atherosclerotic heart disease and hypertensive heart disease.

It is less effective for pulmonary heart disease, active myocarditis (such as active rheumatism) or severe myocardial damage, and is prone to poisoning.

For patients with dilated cardiomyopathy, myocardial hypertrophy, and diastolic heart failure, cardiac glycosides should not be used, but receptor blockers and ACE inhibitors should be the first choice.

atrial fibrillation

atrial flutter

paroxysmal supraventricular tachycardia

tachyarrhythmia

atrioventricular block

sinus bradycardia

visual abnormalities

tachyarrhythmia

antiarrhythmic

Competing NakATPase

Ventricular tachycardia and ventricular fibrillation

Bradycardia, atrioventricular block and other chronic arrhythmias

severe poisoning

Quinidine

Phenytoin

Adrenergic drugs

Potassium-depleting diuretics

Low concentration (D receptor)

acute heart failure, intravenous drip

excited β1

Severe patients who are refractory to cardiac glycosides

Increase cAMP, increase Ca