Muscle relaxants selectively act on skeletal muscle nerve-muscle junctions, bind to N2 choline receptors, and temporarily block the transmission of excitation between nerves and muscles, thereby producing muscle relaxation.

Depolarization type

Non-depolarizing type

Adjuvant medication for general anesthesia (avoid deep anesthesia)

Laryngeal muscle spasm during endotracheal intubation

Prevent muscle spasms caused by certain diagnostic procedures (such as esophagoscopy)

Rehabilitation of bone and joint dislocations and fractures

Controlled ventilation during thoracic and surgical surgery

Controlling muscle spasms in patients with tetanus

composition

N2 choline receptor

α protein subunit of the post-adapter membrane N2 receptor

competitive blocking

non-competitive blocking

Acts on extrasynaptic and presynaptic acetylcholine receptors

Block more than 75%

Block 95%

Restoration time limit

Different receptor distribution densities

amount of blood flow

selective relaxation

High affinity for N₂ receptors

Can bind to N2 and block N1 and M choline receptors

Can cause the release of histamine (induction period of anesthesia)

Highly dissociated polar compounds

Intravenous injection. It is not absorbed orally and is ineffective when injected subcutaneously. The effect of intramuscular injection is only 20% to 50% of that of intravenous injection.

Can bind to mucopolysaccharides, bone and plasma proteins in tissues

Hoffmann elimination and esterase breakdown

pseudocholinesterase

kidney

bile