MindMap Gallery The origin of tumor stem cells and cancer treatment

The origin of tumor stem cells and cancer treatment

The tumor stem cell (TSC) theory revolutionized cancer research, proposing these self-renewing, pluripotent cells drive tumorigenesis, recurrence, and metastasis. TSCs may originate from malignant transformation of normal stem cells or dedifferentiation of mature cells. Conventional therapies often fail to eradicate TSCs, causing relapse. Current research focuses on: developing TSC-surface-marker-targeted drugs, combining immunotherapy with checkpoint inhibitors, and modulating TSC stemness via epigenetic regulation. Recent preclinical studies demonstrate nanoparticle delivery systems significantly enhance TSC targeting efficiency. Future directions emphasize TSC microenvironment modulation and personalized treatment optimization.

Edited at 2024-12-24 12:54:37
WSjgeRkp
WSjgeRkp

The origin of tumor stem cells and cancer treatment

WSjgeRkp
WSjgeRkp
  • Recommended to you
  • Outline