MindMap Gallery The mechanism of X chromosome inactivation
The mechanism of X chromosome inactivation is crucial for ensuring sexual dose compensation in female organisms. It involves the random selection of one X chromosome for inactivation, initiated by the Xist gene and inhibited by the Tsix gene. During inactivation, genes on the X chromosome are silenced, accompanied by epigenetic changes such as DNA methylation and histone modifications. This mechanism not only affects sexual dimorphism but is also closely related to the occurrence of various X-linked genetic diseases.
Edited at 2025-01-11 14:08:57