Essence of coagulation

Activation of the coagulation system

Initial hemostasis (platelet obstruction, white thrombus)

Secondary hemostasis (red thrombus)

Antithrombin III (AT-III)

Protein C (PC)

Protein S(S)

Thrombomodulin (TM)

Under the action of certain pathogenic factors, a large amount of procoagulant substances enter the blood, coagulation factors and platelets are activated, causing an increase in thrombin, and extensive microthrombi are formed in the microcirculation, which in turn causes secondary complications due to a large amount of consumption of coagulation factors and platelets. Fibrinolysis is enhanced, and the body develops a pathological process characterized by hemostasis and coagulation dysfunction.

Infectious diseases

malignant tumor

Obstetric and gynecological diseases

Surgery and Trauma

snake venom

Impaired function of the monocyte-phagocytic system

Severe liver dysfunction

pregnancy

acidosis

microcirculation disorder

Extensive activation of the coagulation system and massive consumption of coagulation factors

Secondary fibrinolytic dysfunction—massive activation of plasmin

Impaired anticoagulant factor pathway

hypercoagulable period

consumptive hypocoagulable phase

Secondary hyperfibrinolytic phase

Bleeding

shock

organ failure

anemia

Prevent and treat primary disease

Improve microcirculation

Establish a new dynamic balance between coagulation, anticoagulation and fibrinolysis