Leaves and fruit of Senna species. Fabaceae Sennosides A and B (Anthraquinones = dianthrone glycosides) Senno. A&B are prodrugs hydrolyzed be flora >>> active metabolites (rhein and rhein anthrone) Cascara & Frangula have milder action than Senna. Senna more widely recommended in atonic constipation. Senna tea (0.5 : 2 g of leaves or fruit) >>> single bowel evacuation within 6 hrs. Senna soaked in cold water for 10-12 hrs is more active than hot tea (more Sennosides) Crystalline Sennosides are available (20-60 mg) >>> They are more stable, more reliable and safer than the preparations of crude drug S.E of long term use:- flatulence, cramping, abdominal pain, discoloration of the urine melanosis of the colon electrolyte imbalance, dehydration and changes in muscular function (chronic constipation).

CAME is nuclear factor KB inhibitor

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