Taken orally
Effective against some enteric gramnegative bacteria. typhoid and dysentery.
Amoxicillin is the drug of choice for upper respiratory
tract infections as it has better absorption
Against Pseudomonas aeruginosa
Carbenicillin
Cephalosporins
First Generation
Cephaloridine:
Gram +ve cocci ,
nephrotoxic
Cephalexin
orally
Second Generation
Cefamandol
Cefoxitin
Active agianst Gram -ve & some anaerobs
Mostly injetion
Third Generation
Ceftazidime
Cefotaxime
More Active than 1st & 2nd
Avtive against Pseudomonas aeruginosa
Fourth Geniration
Cefipime
Cefpirome
Penetrates the outer membrane of Gram negative bacteria faster than third generation
• Administered parentrally