traumatic Injuries: Severe accidents (motor vehicle, industrial, crushing injuries, gunshot wounds, severe burns, explosions) that lead to irreparable tissue damage.
Vascular Diseases: Conditions like peripheral arterial disease (PAD) cause reduced blood flow, tissue damage, and gangrene, necessitating amputation.
Cancer: Certain tumors (bone cancer, soft tissue sarcomas) may require amputation if other treatments are ineffective, to prevent cancer spread and alleviate pain.
Infections: Severe infections affecting bones or soft tissues can lead to tissue death and the need for amputation.
Congenital Conditions: Birth abnormalities or deformities may require amputation to improve functionality or manage associated complications.
Diabetes: Poor circulation and peripheral neuropathy in diabetes can result in chronic wounds, ulcers, infection, and tissue death, sometimes requiring amputation.