MindMap Gallery Primary liver cancer (hepatocellular carcinoma)
Primary liver cancer (hepatocellular carcinoma) mind map, the most common ones are: viral hepatitis → cirrhosis → primary liver cancer, including early liver cancer/small liver cancer, advanced liver cancer, and post-metastasis.
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This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
primary liver cancer (hepatocellular carcinoma)
Cause
Most common: viral hepatitis → cirrhosis → primary liver cancer
Aflatoxin
pathology
Early liver cancer/small liver cancer★
"Pathology" and "Internal Medicine": single <3cm, or the sum of two <3cm
"Surgery" Micro liver cancer ≤3cm, small liver cancer ≤5cm
Advanced liver cancer
"Internal Medicine"
Nodular type
Diffuse type
Blocky shape (most common)
"Pathology" "Surgery"
Nodular type (most common)
Diffuse type
Huge type
transfer
The earliest and most common: intrahepatic hematogenous metastasis to the liver (invasion of the portal vein to form a tumor thrombus)
The earliest and most common lymphatic metastasis: portal lymph nodes
The most common site of extrahepatic blood vessel metastasis: lungs
Implantation transfer
Clinical manifestations of intermediate and advanced liver cancer
Middle-aged and elderly people, more common in men
Pain in the liver area (the most common first symptom): mostly persistent swelling and pain in the right upper abdomen, dull pain
Progressive enlargement of the liver (characteristic manifestation)
Palpable irregular hard nodules
progressive weight loss
If combined with cirrhosis: clinical manifestations and complications of cirrhosis
Persistent irregular low-grade fever
upper gastrointestinal bleeding
Ascites: mostly stubborn and bloody
jaundice
Cirrhosis→Hepatocellular jaundice Late stage liver cancer → obstructive jaundice
hepatic encephalopathy
Vascular murmur heard in abdominal wall
HCC>90% are supplied by the hepatic artery
Lower limb edema
cancer syndrome
Main manifestations: spontaneous hypoglycemia, erythrocytosis
Rare manifestations: hypercalcemia, hyperlipidemia, carcinoid syndrome
Acute abdomen★ (rupture of cancerous tumor on liver surface)
Sudden right upper abdominal pain
mild peritoneal irritation
Blood volume ↓ (sweating, shock)
Auxiliary inspection
Alpha-fetoprotein AFP
screening
Diagnosis (positive rate >70%)
AFP>400ug/L
Or AFP>200ug/L and lasts for 8 weeks
Judgment of efficacy and prediction of recurrence
Film degree exam
Screening: B-ultrasound
Important diagnosis: enhanced CT, enhanced MRI (fast in and fast out)
Optimal imaging examination for diagnosis: selective hepatic arteriography, transarterial chemoembolization tace diagnostic treatment For tiny liver cancers that are difficult to diagnose with enhanced CT and MRI
PET-CT
Gold standard: needle biopsy
treat
Radical surgical resection of liver segments or lobes is preferred
No extrahepatic metastasis
Most suitable for single micro liver cancer and small liver cancer ≤5cm
If it is a single large liver cancer or a giant liver cancer, it should be required to grow outside the liver (destroy <30% of liver tissue) and have a complete tumor capsule (clear surrounding boundaries).
If it is multiple tumors, the number of tumor nodules should be less than 3 and limited to one segment or lobe of the liver.
If the liver function is Child C (jaundice and ascites), no surgery will be performed until the liver function improves.
Not in compliance with surgical indications: TACE→tumor reduction→opportunity for surgery
radiofrequency ablation
Liver transplantation: People with liver cancer that invades blood vessels or develops distant metastasis are not suitable for transplantation
Molecular targeted drugs: multikinase inhibitor (sorafenib)
Systemic chemotherapy and local radiotherapy are not recommended
Treatment of liver cancer rupture and bleeding
The amount of bleeding is not large and the general condition is good: TACE or liver resection
Large amount of bleeding, huge or extensive tumor, uncontrollable during surgery: gauze packing
AFP
Source: Naive liver cells
seen in
HCC
pregnancy
Gonad embryonal tumors: yolk sac tumor/endodermal sinus tumor
Hepatitis, cirrhosis
Not seen in: Cholangiocarcinoma, metastatic liver cancer (such as gastrointestinal cancer)
ALT (reaction to acute hepatocellular necrosis)
Parallel Curves: Active Hepatitis
Curve Separation: Liver Cancer