Extrinsic Pathway (Tissue Factor Initiated)

Intrinsic Pathway (Contact Activation)

Common Pathway (Thrombin Generation, fibrin formation)

Fibrinolysis impairment (reduced plasminogen activator, increased plasminogen activator inhibitor)

Symptoms (Dyspnea, chest pain, hypoxia, organ disfunction)

Laboratory findings (D-dimer, fibrin degradation products, PT/PTT, platlet count)

Imaging (CTPA, ECG)

Anticoagulation (Heparin, Direct Thrombin Inhibitors, NOACs)

Supportive Care (Oxygen therapy, respiratory support)

Thrombolytic therapy (in selected cases of PE)

Pulmonary Thromboembolism (PE)

Microvascular Thrombosis (Organ dysfunction)

Disseminated Intravascular Coagulation (DIC)

Arterial Thrombosis (Stroke, Myocarditis, Myocardial infarction)

Direct Viral Effects

Immune Mediated Mechanisms