Features

Type of infection

microbiological examination

Prevention and control

HSV is transmitted along sensory axons to sensory ganglia and remains latent in nerve cells in a "non-replicating form" for life.

Under non-specific stimulation, latent viruses are activated and infect epithelial cells to cause herpes.

Painful vesicular lesions, primary rather than recurrent infections, may be associated with fever and inguinal lymphadenopathy

Intrauterine/birth canal (common)/postpartum contact infection → herpetic encephalitis and systemic disseminated infection → poor prognosis, high mortality rate / permanent neurological damage is common in survival

Large size and genome

Infected cells will swell and form giant owl-eye-shaped inclusions

Humans are its only natural host and the most common pathogen causing congenital malformations.

All except the respiratory tract

Salivary glands, mammary glands, monocytes, lymphocytes

Congenital infection - neonatal giant cell inclusion disease

perinatal infection

Primary infections in children and adults

transfusion infection

Infection in immunocompromised persons

cytomegalovirus mononucleosis

Malignant lymphoma and nasopharyngeal carcinoma in children are prone to occur in patients with EBV infection

gp350/gp220 binds to the C3d receptor molecule on the surface of B cells and enters the cell

gp85 fusion

latent infection

integrated infection

proliferative infection

lytic infection

Antigens expressed during lytic phase infection

Latent infection expressed antigen

Transmitted by saliva, blood, sexual contact

Widespread infection in the population (first proliferates in oropharyngeal epithelial cells and then infects B cells, which can then cause systemic infection)

The EBV positivity rate among 3-year-old children in my country is >90%

infectious mononucleosis

African childhood lymphoma/Burkitt lymphoma

NK/T cell lymphoma

Nasopharyngeal cancer