It is caused by infection with herpes simplex virus type I. HSV is a DNA virus. Type I mainly causes oral and maxillofacial infections, causing the host to produce a series of immune responses.

Cytotoxicity

Humoral immunity

cellular immunity

Neutrophils, monocytes, macrophages, NK cells and dendritic cells

The incidence of candidiasis is significantly increased in patients with T-cell immunodeficiency, and Candida infection activates cellular immunity.

IL-12 plays an important role

Manifested as type IV hypersensitivity reaction.

It manifests as type I hypersensitivity reaction and may also be type IV.

autoantigen formation

Immune active cells lose the ability to distinguish "self from non-self"

produce autoantibodies

Autoantibodies bind to self-antigens

Infected with human immunodeficiency virus type 1 (HIV-1), the patient's CD4 T cells decrease sharply to the point where they are completely absent.

fungal infection

Bacterial infections

Viral infection

Kaposi's sarcoma, non-Hodgkin's lymphoma

Humoral immunity

cellular immunity

CD4 T cells decreased significantly! The ratio of Th to Ts significantly decreased or even reversed

Abnormal B cell activation, the Ig level in the patient's serum was significantly increased

Macrophages and NK cells function abnormally, their activity decreases, and their chemotactic ability and bactericidal effect decrease.

TSA is only expressed in tumor cells and does not exist in normal cells of the same tissue. Can be recognized by the host's immune system and stimulate the body's immune system to attack and eliminate tumor cells

It also exists in tumor cells and normal cells of the same tissue or cells of other tissues, but the content is different. It is relatively abundant in corresponding tumor tissues, and its content is related to tumor development.

Cytotoxic T cells

natural killer cells

lymphokine-activated killer cells

tumor infiltrating lymphocytes

Lymph node cells in the drainage area of ​​oral and maxillofacial tumors

Monocytes and macrophages

produce antibodies

Monoclonal antibodies are one of the current methods used in tumor immunotherapy

Epidermal growth factor receptor-mediated signal transduction pathway

Immunosuppressive

Immune tolerance