MindMap Gallery Oral Immunology 1
Chapter 4 of Oral Biology, Sections 1 and 2 of Oral Immunology, includes salivary defense, oral mucosal defense, oral lymphoid tissue, etc.
Edited at 2023-11-27 11:49:11This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
oral defense system
salivary defense
non-specific substances
Mucin
Divided into two types, MGI and MGII, they participate in the formation of acquired membranes and inhibit and kill microorganisms.
Lysozyme
Dissolve common oral bacteria and kill oral fungi
Lactoferrin
Interfering with the growth of microorganisms that require iron ions by chelating iron ions
salivary peroxidase
Forms an effective antibacterial system with hydrogen peroxide and thiocyanate
Histone-rich
Kills Candida albicans and Streptococcus mutans
complement
Enhance the clearance of bacteria by phagocytes
sigA
Molecular Structure
An IgA dimer molecule, a secretory component molecule and a J chain.
type
According to the difference in antigenicity, the a chain is divided into two types, constituting two subcategories 1 and 2.
assembly
Function
Tissue microbial adhesion and lysis
Neutralizes viruses and toxins
immune clearance
oral mucosal defense
mucosal innate defense system
mucosal epithelial tissue
Produce defensins that directly kill pathogenic microorganisms
Normal oral flora
Reduce pH, reduce redox potential, compete for nutrients, occupy space and produce a variety of antibacterial substances to inhibit pathogenic bacteria
innate immune cells
adaptive mucosal immune system
mucosal immune system
Including mucosa-associated lymphoid tissue MALT and scattered immune cells. MALT includes gut-associated lymphoid tissue, Waldeyer's loop, and bronchus-associated lymphoid tissue
Source and production of SIgA
oral immune tolerance
By inducing cell death, clonal anergy, and regulatory T cells
oral lymphoid tissue
Extraoral lymph nodes
intraoral lymphoid tissue
tonsil
There are three pairs of palatoglossopharynx. Contains all structural components required for the induction and expression of mucosal antibody responses.
salivary gland lymphoid tissue
Plasma cells account for the majority, producing the majority IgA, and a small amount of IgM and IgG
gingival lymphoid tissue
Submucosal lymphoid tissue and scattered lymphoid cells
Oral immune response characteristics
The oral cavity is a bacterial environment
Oral health is closely related to the integrity of oral mucosa and teeth
Local immune function plays an important role
Immune damage is an important factor in the occurrence of oral diseases
Caries and immunity
The relationship between caries and immunity
non-specific immune molecules
Mucin, lysozyme, lactoferrin, salivary peroxidase, acidic proline-rich protein, histone-rich protein
The relationship between caries and SIgA
Reduced levels of SIgA in saliva increase susceptibility to dental caries.
The main antigenic substance of cariogenic bacteria
Glucosyltransferase
Mediates agglutination and adhesion of bacteria to tooth surfaces
surface antigen protein
Has good immunogenicity and reactogenicity
glucan binding protein
A bacterial glucan receptor mediates the accumulation of bacteria on tooth surfaces.
Research on Immunization to Prevent Caries
active immunity
main immune pathways
oral immunization
The advantages are convenience and safety, but gastric acid and enzymes can destroy antigens. Such as oral capsules.
intranasal immunization
The advantage is that the immune dose requirement is small, easy to operate and easy to accept. Systemic and mucosal immune responses can be induced simultaneously.
Transtonsillar immunization
Produce specific IgA type plasma cell precursor cells, Migrate to salivary glands to produce specific IgA antibodies.
Immunization via minor salivary glands
Induction of salivary SIgA antibody response
Anti-caries vaccine candidates
subunit vaccine
The antigen has a single component, is non-pathogenic, and has a clear immune effect. It is an important research direction for anti-caries vaccines.
Synthetic peptide vaccines
It reduces unnecessary cross-reactions, is convenient to synthesize, but is relatively expensive and has relatively weak immunogenicity.
live bacterial vector vaccine
Commonly used carrier bacteria include Lactobacillus and Salmonella, which induce the body to produce specific anti-caries antibodies.
DNA vaccine
Antigens expressed by cells have the same conformation and antigenicity as natural antigens, are easy to construct, express antigens in the body for a long time, and induce cellular and immune responses at the same time. The production method is relatively simple, has good stability, and is convenient for storage and transportation.
passive immunity
polyclonal antibodies
Monoclonal antibodies
A highly specific antibody produced from a single B cell clone that targets only one epitope of an antigen.
Transgenic plant antibodies
Topical application
Tooth surface smear
Apply Streptococcus mutans-specific exogenous antibodies directly to the tooth surface
Oral rinse
Rinse with special milk regularly