MindMap Gallery Pharmacotherapy of Hypertension
This mind map provides a comprehensive overview of the pharmacotherapy for hypertension, detailing various drug classes and their mechanisms of action, examples, and adverse effects. The main categories include RAAS Inhibitors, Vasodilators, Diuretics, and Sympatholytics. Each category is further divided into specific drug types, such as ACE Inhibitors, Angiotensin II Receptor Blockers, Calcium Channel Blockers, and Beta-Blockers, among others. The map highlights how these drugs function to manage hypertension and the potential side effects associated with each class.
Edited at 2025-10-10 04:06:56This mind map provides a comprehensive overview of the pharmacotherapy for hypertension, detailing various drug classes and their mechanisms of action, examples, and adverse effects. The main categories include RAAS Inhibitors, Vasodilators, Diuretics, and Sympatholytics. Each category is further divided into specific drug types, such as ACE Inhibitors, Angiotensin II Receptor Blockers, Calcium Channel Blockers, and Beta-Blockers, among others. The map highlights how these drugs function to manage hypertension and the potential side effects associated with each class.
Sơ đồ tư duy này cung cấp một cái nhìn tổng quan chi tiết về điều trị tăng huyết áp bằng thuốc, bao gồm các yếu tố quyết định sự kháng thuốc, quản lý dược lý, và các loại thuốc chẹn kênh canxi, thuốc lợi tiểu, và thuốc ức chế men chuyển. Mỗi phần được phân tích chi tiết với cơ chế hoạt động, ví dụ về thuốc, và tác dụng phụ. Ngoài ra, sơ đồ còn đề cập đến các biện pháp không dùng thuốc trong điều trị tăng huyết áp, giúp hiểu rõ hơn về cách kiểm soát huyết áp một cách toàn diện.
This mind map provides a foundational overview of statistics, covering key concepts such as types of variables (quantitative and qualitative), sources of statistical data (primary and secondary), types of statistics (descriptive and inferential), and essential statistical terms (population, sample, parameter, statistic, data, variable, groups). It explains the definition and scope of statistics, highlighting its uses in general contexts, medicine, and pharmacy. The map serves as a comprehensive guide for understanding the basics of statistical analysis and interpretation.
This mind map provides a comprehensive overview of the pharmacotherapy for hypertension, detailing various drug classes and their mechanisms of action, examples, and adverse effects. The main categories include RAAS Inhibitors, Vasodilators, Diuretics, and Sympatholytics. Each category is further divided into specific drug types, such as ACE Inhibitors, Angiotensin II Receptor Blockers, Calcium Channel Blockers, and Beta-Blockers, among others. The map highlights how these drugs function to manage hypertension and the potential side effects associated with each class.
Sơ đồ tư duy này cung cấp một cái nhìn tổng quan chi tiết về điều trị tăng huyết áp bằng thuốc, bao gồm các yếu tố quyết định sự kháng thuốc, quản lý dược lý, và các loại thuốc chẹn kênh canxi, thuốc lợi tiểu, và thuốc ức chế men chuyển. Mỗi phần được phân tích chi tiết với cơ chế hoạt động, ví dụ về thuốc, và tác dụng phụ. Ngoài ra, sơ đồ còn đề cập đến các biện pháp không dùng thuốc trong điều trị tăng huyết áp, giúp hiểu rõ hơn về cách kiểm soát huyết áp một cách toàn diện.
This mind map provides a foundational overview of statistics, covering key concepts such as types of variables (quantitative and qualitative), sources of statistical data (primary and secondary), types of statistics (descriptive and inferential), and essential statistical terms (population, sample, parameter, statistic, data, variable, groups). It explains the definition and scope of statistics, highlighting its uses in general contexts, medicine, and pharmacy. The map serves as a comprehensive guide for understanding the basics of statistical analysis and interpretation.
Pharmacotherapy of Hypertension
Diuretics
Loop
Mechanism of action
Inhibit exchange of Cl-Na-K in the thick segment of the ascending loop of Henle
Not recommended as first-line drugs
Torsemide
Bumetanide
Furosemide
Side effects: Hypokalemia, hypocalcemia, alkalosis, hypotension, hyperuricemia, hyperglycemia, azotemia
Effects
Decreased renal vascular resistance
Increased renal blood flow
Increase Ca+ in urine
Thiazides
Mechanism of action
Inhibit active exchange of Cl-Na to the cortical diluting segment of the ascending loop of Henle
First-line drugs for uncomplicated hypertension
Chlorthalidone
Hydrochlorothiazide
Side effects: Hypokalemia, alkalosis, hypotension, hyperuricemia, ototoxicity
K+-sparing
Mechanism of action
Inhibit reabsorption of Na in the distal convoluted and collecting tubule
Can correct K+ loss (use with thiazide or loop diuretics)
Spirinolactone
Amiloride
Triamterene
Side effects: Produce hyperkalemia (if use with ACE & ARB), spirinolactone can cause gynaecomastia
Effects
Prevent K+ secretion by antagonising aldosterone (spironolactone)
Inhibition by direct aldosterone receptor antagonism and inhibition sodium in CCT (amiloride)
Sympatholytics
Beta-Blockers
E.g., Propranolol, Metoprolol, Atenolol
Mechanism of action
Block beta-adreno-receptors in the heart and periphery causing heart rate and contractility reduces, decreased cardiac output (CO) and blood pressure (BP)
Use
Useful in hypertension when concomitant disease is present
Adverse effects
Bradycardia
Hypotension
Fatigue
Sexual dysfunction
Bronchoconstriction
Warning
Should not be withdrawn abruptly
Contraindicated in uncontrolled asthma
Alpha-Blockers (a1-Blockers)
E.g., Doxazosin, Prazosin
Mechanism of action
Block a1 receptors, leading to vasodilation and reduced peripheral resistance
Use
A choice for hypertension with Benign Prostatic Hyperplasia (BPH) due to smooth muscle relation in the prostate
Adverse effects
Orthostatic hypotension
Dizziness
Headache
Central Sympatholytics
E.g., Methyldopa, Clonidine
Mechanism of action
Stimulate central a2 receptors to reduce norepinephrine (NE) release, thereby reducing sympathetic tone
Adverse effects
Sedation
Dry mouth
Orthostatic hypotension
Withdrawal rebound hypertension
RAAS Inhibitors (Block Renin-Angiotension System
ACE Inhibitors (ACEIs)
E.g., Enalapril, Lisinopril, Ramipril
Mechanism of action
Block the ACE enzyme → reduce Angiotensin II production → reduced vasoconstriction
Adverse effects
Dry cough (due to increased bradykinin)
Angioedema (life-threatening)
Hyperkalemia
Angiotensin II Receptor Blockers (ARBs)
E.g., Losartan, Valsartan, Irbesartan
Mechanism of action
Block Angiotensin II from binding to the AT1 receptor site → vasodilation
Advantage
Less likely to cause cough or angioedema than ACEIs
Both are contraindicated in pregnancy
Direct Renin Inhibitors (DRIs)
E.g., Aliskiren
Mechanism of action
DIrectly inhibit the enzyme renin, preventing the conversion of angiotensinogen to angiotensin I
Vasolidators
Calcium Channel Blockers (CCBs)
E.g., Amlodipine, Nifedipine, Verapamil
Mechanism of action
Block voltage-gated L-type calcium channels → reduce Ca2+ entry into vascular and cardiac smooth muscle cells → relaxation → reduced BP and PR
Classes
Dihydropyridines (DHPs)
E.g., Amlodipine, Nifedipine
Primarily cause vasodilation and may cause reflex tachycardia
Adverse effects
Peripheral edema
Headache
Dizziness
Non-dihydropyridines (Non-DHPs)
E.g., Verapamil, Diltiazem
Have a greater heart depressant effect (reduce heart rate)
Verapamil should not be given with a beta-blocker
Adverse effects
Headache
Dizziness
Bradycardia
Direct Arterial Vasodilators
E.g., Hydralazine, Minoxidil, Sodium nitroprusside
Mechanism of action
Directly relax smooth muscle in the blood vessels → dilation → reduced BP and PR
Hydralazine stimulates NO release
Sodium nitroprusside is a powerful vasodilator used for acute hypertensive crises
Adverse effects
Headache
Tachycardia
Salt & water retention
Sodium nitroprusside carries a risk of cyanide poisoning