A blood

B hematopoietic tissue

A Hematopoietic stem cells (HSC)

B committed progenitor cells

C Hematopoietic microenvironment (HM)

Various types of anemia

Polycythemia

agranulocytosis

Leukemia-like reaction, etc.

inflammatory histiocytosis

infectious mononucleosis

Various types of lymphoma

Acute and chronic lymphocytic leukemia

multiple myeloma

Aplastic anemia (AA)

Paroxysmal nocturnal hemoglobinuria (PNH)

Acute and chronic myeloid leukemia

Shown as reduction of three series

Vascular purpura, such as Henoch-Schonlein purpura

Thrombocytopenic purpura

Blood clotting disorders, such as hemophilia

Disseminated intravascular coagulation (DIC)

1) History of current illness

2) Personal history: history of exposure to radionuclides, drugs, working environment, etc.

3) Genetic history

1) Is there any change in the color of skin and mucous membranes?

2) Whether there is jaundice, bleeding spots, nodules or plaques

3) Whether superficial lymph nodes, liver, and spleen are enlarged

4) Whether there is antionychia or gingival hyperplasia

1) Blood cell count, blood smear cell morphology, bone marrow aspirate fluid smear, etc.

2) Reticulocyte count

3) Bone marrow examination and cytochemical staining

4) Bleeding disease examination

5)Hemolytic disease examination

6) Biochemical and immunological examinations

7) Cytogenetic and molecular biology examination

8) Hematopoietic cell culture and testing technology

9)Instrument inspection

10) Radionuclides

11) Histopathological examination

1) Ultrasound imaging

2) Computerized tomography (CT)

3) Magnetic resonance imaging (MRI)

4) Positron Electron Computed Tomography (PET)

1) Diet and nutritional treatment

2)Psychological and psychiatric treatment

1) Supplement nutrients needed for hematopoiesis

2) Stimulate hematopoiesis

3)Splenectomy

4)Adoptive immunotherapy

5) Component transfusion and use of antibiotics

1) Chemotherapy

2) Radiotherapy

3) Induce differentiation

4) Therapeutic apheresis

5) Immunosuppression

6) Anticoagulation and thrombolytic therapy

HSCT is a comprehensive treatment method that may cure hematological malignancies and genetic diseases.