MindMap Gallery Medicine - Ophthalmology Chapter 10 Lens Disease
An article about medicine - Ophthalmology Chapter 10 Lens disease mind map, including cataracts, abnormal lens position, congenital lens abnormalities, etc.
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This is a mind map about bacteria, and its main contents include: overview, morphology, types, structure, reproduction, distribution, application, and expansion. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about plant asexual reproduction, and its main contents include: concept, spore reproduction, vegetative reproduction, tissue culture, and buds. The summary is comprehensive and meticulous, suitable as review materials.
This is a mind map about the reproductive development of animals, and its main contents include: insects, frogs, birds, sexual reproduction, and asexual reproduction. The summary is comprehensive and meticulous, suitable as review materials.
Chapter 10 Lens Disease
Section 1 Cataract
—Etiology and pathogenesis of cataracts Cataracts are degenerative changes that reduce the optical quality of the lens due to reduced transparency or color change.
2. Clinical manifestations of cataracts
1. symptom
(1) Decreased vision: This is the most obvious and important symptom of cataracts.
(2) Monocular diplopia or polyvision: opacity or water gaps are formed in the lens, making the refractive power of each part of the lens uneven, similar to the effect of a prism, resulting in monocular diplopia or polyvision. See.
2. Signs: Lens opacity can be observed and quantified with the naked eye, spotlight or slit lamp microscope.
3. Description and classification of lens opacity: Lens opacity classification method II (LOCS II) has been used for a long time. The method is to fully dilate the pupil and use slit lamp photography and backlighting.
4. Lens core hardness grading standard: Emery-Little core hardness grading standard divides the core hardness into the following 5 levels: Degree Ⅰ: transparent, coreless, soft; Degree II: The core is yellow-white or yellow, soft core; Grade III: The core is dark yellow and the core is medium hard; Degree IV: The core is brown or amber, hard core; Degree V: The nucleus is brown or black, and the nucleus is extremely hard.
3. Age-related cataracts
Age-related cataracts, also known as senile cataracts, are the most common type of cataracts and are more common in middle-aged and elderly people over 50 years old. The incidence rate increases significantly with age.
clinical manifestations
1.Cortical cataract
This is the most common type of senile cataract. Typical cortical cataracts can be divided into four stages according to the development of their lesions.
(1) Initial stage: Under the slit lamp, vacuoles and water gaps can be seen in the lens cortex. The water gap expands from the periphery to the center Large, wedge-shaped opacity forms in the anterior and posterior cortex around the lens periphery, feather-shaped, with the tip pointing toward the center. Early days The more peripheral opacity does not affect vision, and the disease progresses slowly, taking several years to develop to the next stage.
(2) Expansion stage or immature stage: lens opacity increases, and changes in osmotic pressure cause the cortex to absorb water and swell, and the lens volume decreases. The anterior chamber becomes enlarged and the anterior chamber becomes shallow. Patients with angle-closure glaucoma constitution may induce glaucoma emergency at this time. Sexual seizures. The lens is gray-white and turbid. When examined with oblique illumination, the iris on the projected side is in deep A crescent-shaped shadow formed on the opaque cortex, called iris projection, is characteristic of this period. suffer from The patient's vision decreased significantly and it was difficult to observe the fundus clearly.
(3) Maturity stage: Water in the lens overflows, swelling subsides, the volume becomes smaller, and the depth of the anterior chamber returns to normal. At this point the lens is complete It is completely turbid and milky white, and calcification spots can be seen on the capsule of some patients. The patient's vision can be reduced to hands Movement or light sensation, cannot be seen through the eyes.
(4) Overmaturity period: If the maturity period lasts too long, the water in the lens will continue to be lost after several years, and the lens volume will shrink. Small, with shrinkage of the capsule and the formation of irregular white spots and cholesterol crystals, deepening of the anterior chamber, and vibrating iris trembling. The lens fibers decompose and liquefy, giving a milky white color. The brownish-yellow lens nucleus sinks below the capsular bag and can follow the body Movement due to changes in bits is called a Morgagnian cataract. When the lens nucleus sinks, vision can suddenly improve. Capsular rupture can also cause the nucleus to prolapse. If the dislocated lens or lens nucleus blocks the pupil area, it can also cause the nucleus to protrude. Cause secondary glaucoma.
2. Nuclear cataract: This type of cataract occurs earlier and progresses slowly. The opacity of the nucleus starts from the fetal nucleus or the adult nucleus. The initial nucleus is yellow, which is different from the nuclear sclerosis of normal people. Not easy to distinguish. Nuclear sclerosis is a physiological phenomenon. Due to the lifelong growth of the lens, with age, the density of the lens nucleus gradually increases and the color changes. deep, but has no significant impact on vision. As the disease progresses, the nucleus of nuclear cataract gradually deepens in color and becomes tan, brown, brown-black or even black. color. In the early stage, due to the enhancement of nuclear refractive power, patients may develop phakic myopia, and distance vision declines slowly.
3. Posterior subcapsular cataract
Brownish-yellow opacity appears in the superficial cortex under the posterior capsule of the lens. Because the opacification is located along the visual axis, significant visual impairment occurs early.
treat
1. Cataract drug treatment: Although more than ten kinds of anti-cataract drugs, including traditional Chinese medicine, are currently in clinical use, their efficacy is not very accurate.
2. Cataract surgical treatmentSurgical treatment
It remains the main treatment for all types of cataracts.
Surgical methods
Intracapsular cataract extraction (ICCE): It is a surgery to completely remove the cloudy lens.
Extracapsular cataract extraction (ECCE): It is a surgical procedure that removes the cloudy lens nucleus and cortex while preserving the posterior capsule.
4. Congenital cataract
Congenital cataracts refer to cataracts caused by congenital genetic or developmental disorders that exist before and after birth or gradually develop within one year after birth. Congenital cataract is a common eye disease in children and an important cause of blindness and amblyopia in children. It can occur in one or both eyes, and is sometimes accompanied by other congenital abnormalities of the eye or body.
Cause
Environmental factors: malnutrition during pregnancy, pelvic radiation exposure, taking certain drugs (large doses of tetracyclines, hormones, salicylic acid preparations, anticoagulants, etc.), and systemic diseases (Heart disease, nephritis, diabetes, anemia, hyperthyroidism, tetany, etc.), lack of vitamin D, etc., can all lead to hypodevelopment of the fetal lens.
Clinical manifestations: It can occur in one or both eyes. Most are static, and a few continue to develop after birth. It is generally classified according to the location, shape and degree of lens opacity. congenital cataract causes The location, shape and degree of body opacity are different, and the clinical manifestations are different.
Diagnosis: The diagnosis can be made based on the medical history and lens opacity pattern.
treat
For total cataracts in both eyes or cataracts located in the center of the visual axis with obvious turbidity, as well as cataracts affecting vision in one eye, surgery should be performed between 2 and 6 months based on the development of the eyeballs under the premise of general anesthesia after birth. For patients with cataracts in both eyes, after surgery on one eye, surgery on the other eye should be completed within 2 weeks to 1 month.
Taking into account the development of the eyes of infants and young children, it is generally believed that intraocular lens implantation surgery is performed around the age of 2 years.
5. Traumatic cataract
Lens opacity caused by blunt eyeball trauma, perforation injury, and explosion injury is called traumatic cataract. It is more common in children or young adults and often occurs in one eye.
Etiology and clinical manifestations
Cataracts caused by blunt trauma to the eye: During the contusion, the iris pigment epithelium at the edge of the pupil ruptures and falls off, and is attached to the front surface of the lens, which is called Vossius ring opacity, and the corresponding Subcapsular opacity appears, which may disappear after a few days, or may persist for a long time.
Treatment: When the lens opacity is obvious and affects vision, cataract removal should be performed. Since most traumatic cataracts occur in one eye, an intraocular lens should be implanted at the same time as possible after cataract removal. body.
6. Metabolic cataract
Lens opacification caused by metabolic disorders is called metabolic cataract.
1. Galactose cataract
Treatment: Giving a lactose- and galactose-free diet can control the progression of the disease.
2. Tetany cataract: also known as hypocalcic cataract. Caused by low serum calcium. Patients with low calcium often have tetany, so it is called tetany cataract.
7. Complicated cataracts
Complicated cataracts are clouding of the lens caused by eye disease.
Cause: Due to eye inflammation or degenerative lesions, the nutrition or metabolism of the lens is impaired, resulting in its opacity. Commonly seen in uveitis, retinitis pigmentosa, retinal detachment, glaucoma, Intraocular tumors and high myopia, etc.
Clinical manifestations: Patients have symptoms of the primary disease, which can occur in both eyes or one eye. Diseases caused by anterior segment disease mostly start in the anterior cortex. Caused by diseases of the posterior segment of the eye, early stage in the capsule of the posterior pole of the lens Granular gray-yellow opacity appeared in the subcapsular and subcapsular cortex, and more vacuoles were formed, which gradually expanded to the center and periphery of the lens nucleus in a radial shape, forming a rosette-like opacity, which continued It spreads to the anterior cortex and gradually makes the lens completely opaque. High myopia is mostly caused by nuclear cataracts.
8. Drugs and toxic cataracts: Long-term application or exposure to drugs or chemicals that have toxic effects on the lens can cause lens opacity. So far, more than 50 such substances with different structures have been discovered.
9. Radioactive cataracts
The electromagnetic spectrum from gamma rays to protons, neutrons, electrons, microwave radiation, etc. can cause lens opacity. Lens opacity caused by radiation is called radioactive cataract.
Etiology and clinical manifestations
1. Cataracts caused by infrared rays: After short-wave infrared rays are absorbed by the lens, lens opacity occurs.
10. Posterior cataract
After extracapsular cataract removal (including phacoemulsification) or after lens trauma, the remaining cortical or lens epithelial cells proliferate and form opacity, which is called post-onset cataract. What occurs after cataract surgery is also called posterior capsular opacification. It is the most common complication after extracapsular cataract extraction.
Clinical manifestations: The incidence of posterior capsule opacification of the lens after extracapsular cataract extraction can be as high as 30% to 50% over 3 years. It almost always occurs after childhood cataract surgery. Posterior lens capsule appears thick Thin, unevenly organized tissue and Elschnig bead-like bodies.
Treatment: When post-cataract affects vision, Nd:YAG laser can be used to incise the posterior capsule of the lens in the pupil area. If laser treatment is unavailable or the posterior capsule is too thick to be treated with laser, Surgery may be performed to puncture or cut the posterior capsule of the lens in the pupillary area.
Section 2 Abnormal lens position
If the position of the lens changes after birth due to congenital factors, trauma or some diseases, it is called lens dislocation.
clinical manifestations
1. Total lens dislocation
All the zonular ligaments of the lens are broken, and the lens can be dislocated to the following locations.
(1) In the anterior chamber: the lens often sinks below the anterior chamber, with a golden sheen on the edge, making the transparent lens look like an oil droplet.
(2) In the vitreous cavity
(3) The lens is embedded in the pupil area: part of the lens protrudes into the anterior chamber, affecting the aqueous humor circulation and causing an acute increase in intraocular pressure.
(4) The lens is dislocated outside the eyeball: When the lens is completely dislocated and leaves the pupil area, the vision of the affected eye becomes aphakic, the anterior chamber deepens, and the iris vibrates. trembling.
2. Lens subluxation
Part of the lens can be seen in the pupil area, and part of the equatorial part of the lens can be seen after dilating the pupil. The suspensory ligament in this area is broken. Monocular diplopia can occur after lens subluxation. One image is formed through the lens area, and the other is smaller and is seen through the aphakic area.
treat
Surgical treatment: The dislocated lens dissolves and becomes cloudy, causing serious complications.
Section 3 Congenital lens anomalies
Abnormal lens morphology
clinical manifestations
1. Spherical lens: also known as small lens, mostly bilateral. The lens is spherical, with a small diameter and a long front-to-back diameter.
2. Conical lens: The front or back of the lens protrudes and is cone-shaped. It is usually cortical protrusion and mostly occurs in the late fetal period or after birth. for rare Congenital anomalies of the lens, with anterior conus being more rare, are often accompanied by congenital cataracts and high myopia.
3. Umbilical lens defect: extremely rare. A small depression on the front or back surface of the lens.