red blood cellsRBC

Hemoglobin concentration Hb

HematocritHCT

mean corpuscular volumeMCV

Mean corpuscular hemoglobin MCH

mean corpuscular hemoglobin concentration MCHC

Red blood cell volume distribution width RDW

RET increased significantly

RET is significantly reduced

myelopathic anemia

The diameter of the central light-stained area is less than 1/3 of the cell diameter

Abnormal size

Abnormal morphology

abnormal staining

Structural abnormality

Distribution anomaly

Changes in certain components in plasma

Decreased number of red blood cells

pathological increase

The first stage: hematopoietic stem cell stage

Stage 2: Hematopoietic progenitor cell stage

The third stage: primitive cell proliferation and maturation stage

acute blood loss

chronic blood loss

Hematopoietic tissue damage

Reduced or lost utilization of hematopoietic raw materials

RBC's own flaws

RBC external defects

RBC, Hb decreased, Hb was more significant; MCV, MCH, MCHC decreased, RDW increased significantly; blood film: microcytic hypopigmentation, red blood cell body is small, central light-stained area is expanded, and cell size is uneven

The proliferation of nucleated cells is obviously active, and the granulosa/red ratio decreases; the number of immature red blood cells increases significantly: >30%, mainly in the middle and late immature erythrocytes; immature plasma and old nuclei; mature erythrocytes: varying sizes, with an increase in small erythrocytes and a pale center The dyeing area expands

intracellular iron

extracellular iron

The gold standard reflecting body iron storage

RBC, Hb decreased, RBC was more significant; MCV, MCH increased, RDW increased significantly; blood film: red blood cells were uneven in size, mainly one large cell, and the light-stained area in the center shrank.

Hyperplasia is obviously active

Erythroid hyperplasia, immature erythrocytes >40%, giant promyoerythrocytes, giant and medium-sized erythrocytes, and giant promyoblasts can be seen; "young nuclei and old plasma"; different sizes, large red blood cells increase, and the center light-stained area shrinks

It is an important coenzyme for synthesizing DNA. MA must be tested.

intravascular hemolysis

extravascular hemolysis

RBC self-defects: often lead to congenital hemolytic anemia

RBC external defects: often lead to acquired hemolytic anemia

Mostly normocytic normochromic anemia, with reduced RBC, Hb and Hct; mature red blood cells in blood smears vary in size; Rct increases significantly

Bone marrow proliferation is obviously active, and the granulosa-red ratio is significantly reduced or even inverted; erythroid hyperplasia is obvious, and young red is often >40%

Blood

bone marrow

Hematopoietic stem cell count

Blood

bone marrow

Hematopoietic stem cell count