The cell wall contains a large amount of lipids, mainly mycolic acid

Generally not easy to color, but it can be colored by heating or extending the dyeing time. After coloring, it resists decolorization by acidic alcohol.

The shape is slender and slightly curved, arranged in a branch-like shape.

G

The bacterial cells are slender and slightly curved, arranged in a branching shape.

Zini acid-fast stain

The cell wall has an outer membrane layer similar to G-: peptidoglycolipid mycolic acid

Bacteria cannot synthesize lipids on their own and need a culture medium to provide them.

Mycobacterium tuberculosis catalase test, thermal catalase test-

Non-tuberculous mycobacteria catalase test, thermal catalase test

Mycobacterium tuberculosis can synthesize nicotinic acid and reduce nitrate, but Mycobacterium bovis cannot

Resistant to dryness, acid and alkali, penicillin

Afraid of heat, humidity, alcohol, and ultraviolet rays

Bacterial proteins and glycolipids stimulate T lymphocytes to form a hypersensitive state

Sensitized T lymphocytes encounter Mycobacterium tuberculosis again and release cytokines, causing type IV hypersensitivity reaction, mononuclear cell infiltration → caseous necrosis, and liquefaction into cavities.

BCG vaccine—attenuated strain of Mycobacterium bovis (BCG) can be developed

Funicular factor (TDM)/trehalose 6’6-dimycolic acid

Mannolipids

cerebroside sulfate

Phospholipids

waxy D(mAGP)

tuberculin

tuberculosis

Not tuberculosis (mostly related to Mycobacterium tuberculosis L type)

principle

Tuberculin Reagent—Pure Protein Derivative (PPD)

method

application

result

foam cell production

Typical intracellular bacteria cannot be cultivated artificially

Animal model—armadillo

Strong, resistant to drying and low temperature

Uncategorized

Tuberculoid type

Boundary class

Tumor type

Tumor leprosy positive

Tuberculoid leprosy negative